Effect of combined oral contraceptive use on verbal memory function in healthy women.

IF 3.2 3区 医学 Q2 PSYCHIATRY
Mette C Hochheim, Vibe G Frokjaer, Søren V Larsen, Vibeke H Dam
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Abstract

Purpose: Female sex hormones as well as the synthetic hormones contained within combined oral contraceptives (COCs) may influence emotional and cognitive functioning including learning and memory; however, findings are inconsistent. We here present the largest study to date investigating the effect of COC use on verbal memory in healthy women.

Methods: COC use and verbal memory scores were available from the CIMBI database for 205 healthy women in the reproductive age. We assessed if verbal memory and affective bias differed between COC users and non-users. In a subgroup of natural cycling women in the follicular phase, we assessed if verbal memory was associated with plasma estradiol levels.

Results: We found no statistically significant group differences in either overall memory performance (p = 0.16) or affective memory bias (p = 0.18) between COC users and non-users, although there was a trend suggesting COC users may exhibit slightly better recall for short-term (p = 0.09) and long-term task (p = 0.08) conditions. Similarly, COC users tended to have slightly better overall memory compared with women in the follicular phase (p = 0.05). Follicular phase plasma estradiol levels were not associated with verbal memory.

Conclusions: We found no support for COC use to negatively impact verbal memory, if anything COC users tended to perform better than natural cycling women in follicular phase; however, this could be influenced by a healthy user bias. In conclusion, these findings highlight that women who tolerate COCs well should not be concerned about potential adverse effects on memory.

复方口服避孕药对健康女性言语记忆功能的影响。
目的:女性性激素以及复方口服避孕药(COCs)中所含的合成激素可能影响情绪和认知功能,包括学习和记忆;然而,研究结果并不一致。我们在此提出了迄今为止调查COC使用对健康女性言语记忆影响的最大研究。方法:从CIMBI数据库中获取205名育龄健康妇女的COC使用和言语记忆评分。我们评估了COC使用者和非使用者之间的言语记忆和情感偏差是否存在差异。在卵泡期自然周期女性亚组中,我们评估了言语记忆是否与血浆雌二醇水平相关。结果:我们发现COC使用者和非使用者在整体记忆表现(p = 0.16)或情感记忆偏差(p = 0.18)方面没有统计学上的显著差异,尽管有趋势表明COC使用者可能在短期(p = 0.09)和长期任务(p = 0.08)条件下表现出稍好的回忆。同样,与处于卵泡期的女性相比,COC使用者的整体记忆力略好(p = 0.05)。卵泡期血浆雌二醇水平与言语记忆无关。结论:我们没有发现COC使用对言语记忆有负面影响的证据,如果有的话,COC使用者倾向于在卵泡期比自然循环的女性表现更好;然而,这可能受到健康用户偏见的影响。总之,这些发现强调,对COCs耐受良好的女性不应担心对记忆的潜在不利影响。
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来源期刊
Archives of Women's Mental Health
Archives of Women's Mental Health 医学-精神病学
CiteScore
8.00
自引率
4.40%
发文量
83
审稿时长
6-12 weeks
期刊介绍: Archives of Women’s Mental Health is the official journal of the International Association for Women''s Mental Health, Marcé Society and the North American Society for Psychosocial Obstetrics and Gynecology (NASPOG). The exchange of knowledge between psychiatrists and obstetrician-gynecologists is one of the major aims of the journal. Its international scope includes psychodynamics, social and biological aspects of all psychiatric and psychosomatic disorders in women. The editors especially welcome interdisciplinary studies, focussing on the interface between psychiatry, psychosomatics, obstetrics and gynecology. Archives of Women’s Mental Health publishes rigorously reviewed research papers, short communications, case reports, review articles, invited editorials, historical perspectives, book reviews, letters to the editor, as well as conference abstracts. Only contributions written in English will be accepted. The journal assists clinicians, teachers and researchers to incorporate knowledge of all aspects of women’s mental health into current and future clinical care and research.
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