Polydopamine-Modified Composite Bone Cement for Cancellous Bone Repair: Synergism of Bioactivity, Antibacterial Properties, and Biodegradability

IF 5.5 2区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomacromolecules Pub Date : 2025-06-09 DOI:10.1021/acs.biomac.5c00157

Yalan Ouyang , Rongguang Zhang , Qiyi Zhang , Yonggang Yan

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Abstract

Infection-prone bone defects require multifunctional materials. We developed a novel degradable composite bone cement: polydopamine-modified calcium polyphosphate (CPP@PDA) combined with tricalcium silicate (C₃S). CPP@PDA provides bioactivity and antibacterial effects, while C₃S ensures sustained bioactive ion release. The cement exhibited >74% antibacterial efficacy (Staphylococcus aureus, Escherichia coli), with bacterial survival at 15.9 ± 1.2% and 26.1 ± 0.8%. Controlled degradation released Ca²⁺ and silicon species, stimulating osteogenesis, shown by increased alkaline phosphatase (ALP) activity and upregulated RUNX2, COL1, and OPN markers. The material also demonstrated antioxidant and antiinflammatory properties, reducing oxidative stress and modulating immune responses to support bone regeneration. This CPP@PDA composite cement, with synergistic antibacterial, biodegradable, and osteogenic functionalities, shows significant potential for treating infection-prone cancellous bone defects.

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查看原文本刊更多论文

用于松质骨修复的多多巴胺改性复合骨水泥：生物活性、抗菌性能和生物降解性的协同作用。

易感染骨缺损需要多功能材料。我们开发了一种新型的可降解复合骨水泥：聚多巴胺修饰的聚磷酸钙（CPP@PDA）结合硅酸三钙（C3S）。CPP@PDA提供生物活性和抗菌作用，而C3S确保持续的生物活性离子释放。该水泥对金黄色葡萄球菌、大肠杆菌的抗菌效果为50.74%，细菌存活率分别为15.9±1.2%和26.1±0.8%。控制降解释放Ca2+和硅物质，刺激成骨，表现为碱性磷酸酶（ALP）活性增加和RUNX2， COL1和OPN标记上调。该材料还显示出抗氧化和抗炎特性，减少氧化应激和调节免疫反应，以支持骨再生。这种CPP@PDA复合水泥具有协同抗菌、可生物降解和成骨功能，在治疗容易感染的松质骨缺损方面显示出巨大的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomacromolecules 化学-高分子科学

CiteScore

10.60

自引率

4.80%

发文量

417

审稿时长

1.6 months

期刊介绍： Biomacromolecules is a leading forum for the dissemination of cutting-edge research at the interface of polymer science and biology. Submissions to Biomacromolecules should contain strong elements of innovation in terms of macromolecular design, synthesis and characterization, or in the application of polymer materials to biology and medicine. Topics covered by Biomacromolecules include, but are not exclusively limited to: sustainable polymers, polymers based on natural and renewable resources, degradable polymers, polymer conjugates, polymeric drugs, polymers in biocatalysis, biomacromolecular assembly, biomimetic polymers, polymer-biomineral hybrids, biomimetic-polymer processing, polymer recycling, bioactive polymer surfaces, original polymer design for biomedical applications such as immunotherapy, drug delivery, gene delivery, antimicrobial applications, diagnostic imaging and biosensing, polymers in tissue engineering and regenerative medicine, polymeric scaffolds and hydrogels for cell culture and delivery.