Loeffler endocarditis revealing chronic eosinophilic leukaemia with FIP1L1-PDGFRA rearrangement: a case report.

IF 0.8 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS

European Heart Journal: Case Reports Pub Date : 2025-05-02 eCollection Date: 2025-05-01 DOI:10.1093/ehjcr/ytaf218

Raid Faraj, Zineb El Bougrini, Aatif Benyass, Youssef Sekkach, Ilyasse Asfalou

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Abstract

Background: Hypereosinophilic syndrome (HES) is an infrequent multisystemic disorder with a serious prognosis, defined by persistent marked eosinophilia (>1500 eosinophils/mm3) associated with organ damage from eosinophil-mediated cytotoxicity. Cardiac involvement is a significant and unpredictable complication of hypereosinophilic syndrome, particularly prevalent in patients carrying the FIP1L1-PDGFRA fusion.

Case summary: Reported is a case of chronic eosinophilic leukaemia (CEL) with a FIP1L1-PDGFRA rearrangement, diagnosed in a 31-year-old patient presenting with Loeffler endocarditis. Intracardiac thrombi and embolic cerebral infarctions complicated the case. The patient demonstrated haematological remission following chemotherapy, and anticoagulation treatment led to thrombi resolution.

Discussion: This case highlights that Loeffler endocarditis can present as the primary and sole manifestation of chronic eosinophilic leukaemia. Effective collaboration between cardiologists and internists is crucial for timely diagnosis and comprehensive management, ultimately resulting in enhanced outcomes.

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伴有FIP1L1-PDGFRA重排的慢性嗜酸性粒细胞白血病1例。

背景：高嗜酸性粒细胞综合征（HES）是一种罕见的多系统疾病，预后严重，定义为持续显著的嗜酸性粒细胞增多（>1500嗜酸性粒细胞/mm3），并伴有嗜酸性粒细胞介导的细胞毒性引起的器官损伤。心脏受累是高嗜酸性粒细胞综合征的重要且不可预测的并发症，特别是在携带FIP1L1-PDGFRA融合的患者中。病例总结：报告一例慢性嗜酸性粒细胞白血病（CEL）伴FIP1L1-PDGFRA重排，诊断为31岁的Loeffler心内膜炎患者。心内血栓和栓塞性脑梗死使该病例复杂化。患者在化疗后表现出血液学缓解，抗凝治疗导致血栓消退。讨论：本病例强调吕弗勒心内膜炎可以作为慢性嗜酸性粒细胞白血病的主要和唯一表现。心脏病专家和内科医生之间的有效合作对于及时诊断和全面管理至关重要，最终导致增强的结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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