AgOTf-Catalysed Regioselective C1-Amination of Pyrrolo[1,2-a]quinoxaline With Azodicarboxylates

IF 3.7 2区化学 Q2 CHEMISTRY, APPLIED

Applied Organometallic Chemistry Pub Date : 2025-05-19 DOI:10.1002/aoc.70228

Wanqiang Wang, Jing Guo, Di Hao, Yishi Guo, Jianshu Zhang, Ping Liu

引用次数: 0

Abstract

AgOTf-catalysed regioselective C1-amination of pyrrolo[1,2-a]quinoxaline has been developed. The reaction allowed the use of various pyrrolo[1,2-a]quinoxalines and azodicarboxylates as coupling partners to afford C1-aminated products with good to excellent yields. The synthetic strategy showed excellent regioselectivity, functional group tolerance as well as gram-scale synthesis. The amination products were further modified to furnish structurally diverse pyrrolo[1,2-a]quinoxaline compounds.

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agotf催化吡咯[1,2-a]喹啉与偶氮二羧酸的区域选择性c1 -胺化反应

研究了agotf催化吡咯[1,2-a]喹啉的区域选择性c1胺化反应。该反应允许使用各种吡咯[1,2-a]喹诺啉和偶氮二羧酸作为偶联物，以获得收率良好至优异的c1胺化产物。该合成策略具有良好的区域选择性、官能团耐受性和克级合成能力。进一步对胺化产物进行改性，得到结构多样的吡咯[1,2-a]喹啉化合物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Applied Organometallic Chemistry 化学-无机化学与核化学

CiteScore

7.80

自引率

10.30%

发文量

408

审稿时长

2.2 months

期刊介绍： All new compounds should be satisfactorily identified and proof of their structure given according to generally accepted standards. Structural reports, such as papers exclusively dealing with synthesis and characterization, analytical techniques, or X-ray diffraction studies of metal-organic or organometallic compounds will not be considered. The editors reserve the right to refuse without peer review any manuscript that does not comply with the aims and scope of the journal. Applied Organometallic Chemistry publishes Full Papers, Reviews, Mini Reviews and Communications of scientific research in all areas of organometallic and metal-organic chemistry involving main group metals, transition metals, lanthanides and actinides. All contributions should contain an explicit application of novel compounds, for instance in materials science, nano science, catalysis, chemical vapour deposition, metal-mediated organic synthesis, polymers, bio-organometallics, metallo-therapy, metallo-diagnostics and medicine. Reviews of books covering aspects of the fields of focus are also published.