QTc Interval Dispersion in Pediatric Epilepsy: A Case–Control Study From Iran

IF 1.1 4区医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS

Annals of Noninvasive Electrocardiology Pub Date : 2025-05-20 DOI:10.1111/anec.70094

Ahmad Talebian, Ali Mohammad Shakiba, Adele Malekipoor, Fatemeh Hafezipour, Mohammad Mahdi Heidari, Fatemeh Talebian, Hamid Reza Gilasi

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引用次数: 0

Abstract

Introduction

QT interval corrected dispersion (QTcd) reflects the heterogeneity of ventricular repolarization and has been proposed as a marker for arrhythmic risk in various neurologic and cardiac conditions. The aim of this study was to evaluate QTcd differences between children with epilepsy and healthy controls, with attention to age and antiepileptic drug use.

Methods

A case–control study was conducted on 50 children with epilepsy and 50 age- and sex-matched control children admitted to Shahid Beheshti Hospital in Kashan in 2019. QTcd was manually measured from 12-lead electrocardiograms (ECGs). Data were analyzed using SPSS version 22.

Results

No overall significant difference was observed in QTcd between groups (p > 0.05). However, children with epilepsy under 5 years of age had significantly higher QTcd than controls of the same age (p = 0.014). Moreover, QTcd was significantly lower in children with epilepsy receiving medication compared with those not on treatment (p = 0.026).

Conclusion

Although overall QTcd did not differ significantly between epileptic and control children, age under five and antiepileptic drug use significantly influenced QTcd. These findings suggest the importance of cardiac evaluation and early treatment in younger patients with epilepsy.

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小儿癫痫QTc间期离散度：来自伊朗的病例对照研究

QT间期校正离散度（QTcd）反映了心室复极的异质性，并被认为是各种神经和心脏疾病中心律失常风险的标志。本研究的目的是评估癫痫患儿与健康对照之间的QTcd差异，并注意年龄和抗癫痫药物的使用。方法对2019年卡尚市沙希德·贝赫什蒂医院收治的50例癫痫患儿和50例年龄、性别匹配的对照组患儿进行病例对照研究。QTcd由12导联心电图（ECGs）人工测量。数据分析采用SPSS version 22。结果两组间QTcd总体差异无统计学意义（p > 0.05）。而5岁以下癫痫患儿的QTcd明显高于同龄对照组（p = 0.014）。此外，接受药物治疗的癫痫患儿的QTcd明显低于未接受药物治疗的癫痫患儿（p = 0.026）。结论癫痫患儿与对照组总体QTcd差异不显著，但5岁以下儿童和抗癫痫药物使用对QTcd有显著影响。这些发现提示对年轻癫痫患者进行心脏评估和早期治疗的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Noninvasive Electrocardiology 医学-心血管系统

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The ANNALS OF NONINVASIVE ELECTROCARDIOLOGY (A.N.E) is an online only journal that incorporates ongoing advances in the clinical application and technology of traditional and new ECG-based techniques in the diagnosis and treatment of cardiac patients. ANE is the first journal in an evolving subspecialty that incorporates ongoing advances in the clinical application and technology of traditional and new ECG-based techniques in the diagnosis and treatment of cardiac patients. The publication includes topics related to 12-lead, exercise and high-resolution electrocardiography, arrhythmias, ischemia, repolarization phenomena, heart rate variability, circadian rhythms, bioengineering technology, signal-averaged ECGs, T-wave alternans and automatic external defibrillation. ANE publishes peer-reviewed articles of interest to clinicians and researchers in the field of noninvasive electrocardiology. Original research, clinical studies, state-of-the-art reviews, case reports, technical notes, and letters to the editors will be published to meet future demands in this field.