Polymorphisms in the FTO Gene and Their Association With Cancer Risk: A Comprehensive Review and Meta-Analysis

IF 1.5 Q4 ONCOLOGY

Cancer reports Pub Date : 2025-05-20 DOI:10.1002/cnr2.70162

Fengran Guo, Yilong Gao, Hu Wang, Pengfei Zhou, Yanping Zhang, Zhihai Teng, Yaxuan Wang, Zhenwei Han

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Abstract

Background

This meta-analysis aimed to clarify the connection between six polymorphisms in the FTO gene and susceptibility to cancer.

Methods

The relevant literature on the relationship between FTO variants and cancer susceptibility was comprehensively gathered from PubMed, Scopus, Embase, Medline, and Web of Science prior to May 20, 2024.

Results

Our analysis revealed that FTO rs9939609 had a certain correlation with an elevated cancer risk within the Asian demographic q vs. r (OR = 1.22, 95% CI = 1.07–1.39, p = 0.003); rq + qq vs. rr (OR = 1.18, 95% CI = 1.04–1.35, p = 0.011); qq vs. rr + rq (OR = 1.78, 95% CI = 1.39–2.27, p = 0.001). Additionally, FTO rs1477196 was linked to a higher risk of thyroid cancer qq vs. rr + rq (OR = 1.47, 95% CI = 1.13–1.91, p = 0.004) and remarkably relevant to an increased cancer susceptibility for Caucasians (q vs. r (OR = 1.29, 95% CI =1.06–1.57, p = 0.009); rq + qq vs. rr (OR = 1.37, 95% CI = 1.04–1.80, p = 0.024)). In the stratified analysis of rs8047395, the results indicated that rs8047395 had a certain correlation with cancer susceptibility for thyroid cancer q vs. r (OR = 1.23, 95% CI = 1.01–1.51, p = 0.041) and qq vs. rr + rq (OR = 1.53, 95% CI = 1.24–1.91, p < 0.01).

Conclusion

FTO rs9939609 showed a correlation with cancer risk among individuals of Asian descent. FTO rs1477196 was correlated with an increased risk for thyroid cancer and remarkably relevant to an increased cancer susceptibility for Caucasians. FTO rs8047395 was associated with the risk of thyroid cancer.

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FTO基因多态性及其与癌症风险的关系：一项综合综述和荟萃分析

本荟萃分析旨在阐明FTO基因的6个多态性与癌症易感性之间的联系。方法综合收集2024年5月20日之前PubMed、Scopus、Embase、Medline和Web of Science中FTO变异与癌症易感性关系的相关文献。结果我们的分析显示，FTO rs9939609与亚洲人口统计学中癌症风险升高有一定的相关性（OR = 1.22, 95% CI = 1.07-1.39, p = 0.003）；中移动+ qq与rr (OR = 1.18, 95% CI -1.35 = 1.04, p = 0.011);qq和rr + rq (OR = 1.78, 95% CI -2.27 = 1.39, p = 0.001)。此外，FTO rs1477196与甲状腺癌高风险qq与rr + rq相关（OR = 1.47, 95% CI = 1.13-1.91, p = 0.004），与高加索人癌症易感性增加显著相关(q vs r (OR = 1.29, 95% CI = 1.06-1.57, p = 0.009)；中移动+ qq与rr (OR = 1.37, 95% CI -1.80 = 1.04, p = 0.024)。在rs8047395的分层分析中，结果显示rs8047395与甲状腺癌的癌症易感性q vs. r （OR = 1.23, 95% CI = 1.01-1.51, p = 0.041）、qq vs. rr + rq （OR = 1.53, 95% CI = 1.24-1.91, p < 0.01）有一定的相关性。结论FTO rs9939609基因与亚洲人癌症风险相关。FTO rs1477196与甲状腺癌风险增加相关，与白种人癌症易感性增加显著相关。FTO rs8047395与甲状腺癌风险相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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