The Deteriorated Center-Surround Suppression in Patients With First-Episode and Drug-Naïve Major Depressive Disorder

IF 3.3 2区医学 Q1 PSYCHIATRY

Depression and Anxiety Pub Date : 2025-05-20 DOI:10.1155/da/7376934

Yunyue Zhuang, Weijie Song, Shenbing Kuang, Wei Li, Shujuan Pan, Zhiren Wang, Wei Qu, Jingxu Chen, Yunlong Tan, Chundi Wang, Hu Deng

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引用次数: 0

Abstract

Background: Major depressive disorder (MDD) patients are often associated with inhibition deficits in the visual cortex. Most previous research has focused on visual inhibition in MDD patients during acute and remission phases, with little research on first-episode and drug-naïve (FEDN) patients. To fill this gap, we psychophysically investigated the inhibitory process of visual motion in patients with FEDN MDD.

Methods: Two psychophysical tasks: Center-Surround Suppression (CSS) and Motion Repulsion (MR) were utilized to investigate the presence of visual perceptual inhibition deficits in patients with FEDN MDD. We collected data from 74 patients with FEDN MDD and 68 healthy controls (HCs) matched for age, years of education, and gender. We also measured the Hamilton Depression Rating Scale, 17-item (HAMD-17) for each patient to assess the severity of depressive symptoms.

Results: The results showed that CSS was significantly deteriorated in FEDN MDD patients (p = 0.001), but it did not correlate with the HAMD score (p > 0.05). In addition, no significant differences were observed between the two groups of subjects in terms of gender, age, and education level (all p > 0.05). Analysis of two previously published datasets using the same CSS task involving MDD patients in different illness stages revealed that the levels of CSS reduction in our FEDN patients were also significantly distinguishable from those in acute and recovered MDD patients (all p < 0.01). This quantitative comparison indicates that CSS impairments are dynamic over the course of illness development. Moreover, the magnitudes of MR showed no significant differences between MDD patients and HCs (all p > 0.05).

Conclusions: Our study was the first to demonstrate the deteriorated CSS in patients with FEDN MDD. Notably, inhibitory deficits in MDD are also highly specific, as MDD affects only the CSS, but not the MR. Therefore, the discrepancy between these two psychophysical tasks suggests CSS may serve as a feasible early marker in MDD. These findings offer new insights into the specific visual cortical deficits in patients with FEDN MDD.

Limitation: The current study lacks imaging data to support the perceptual phenomenon we observed.

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首发和Drug-Naïve重度抑郁障碍患者中心-环绕抑制恶化

背景：重度抑郁症（MDD）患者通常与视觉皮层的抑制缺陷有关。大多数先前的研究都集中在重度抑郁症患者急性期和缓解期的视觉抑制上，而对首发和drug-naïve （FEDN）患者的研究很少。为了填补这一空白，我们从心理物理角度研究了FEDN MDD患者的视觉运动抑制过程。方法：采用中心-环绕抑制（CSS）和运动排斥（MR）两项心理生理任务研究FEDN重度抑郁症患者视觉知觉抑制缺陷的存在。我们收集了74例FEDN MDD患者和68例年龄、受教育年限和性别匹配的健康对照（hc）的数据。我们还测量了汉密尔顿抑郁评定量表，17项（HAMD-17）为每个患者评估抑郁症状的严重程度。结果：结果显示，FEDN MDD患者的CSS明显恶化（p = 0.001），但与HAMD评分无相关性(p >；0.05)。此外，两组受试者在性别、年龄和受教育程度方面均无显著差异(p >；0.05)。对两个先前发表的数据集进行分析，使用相同的CSS任务，涉及不同疾病阶段的MDD患者，结果显示，FEDN患者的CSS降低水平与急性和康复期MDD患者的CSS降低水平也有显著差异(p <；0.01)。这种定量比较表明，CSS损伤在疾病发展过程中是动态的。此外，MDD患者和hc患者的MR值无显著差异(p >；0.05)。结论：我们的研究首次证实了FEDN MDD患者的CSS恶化。值得注意的是，MDD的抑制性缺陷也是高度特异性的，因为MDD只影响CSS，而不影响mr。因此，这两种心理生理任务之间的差异表明CSS可能是MDD的一个可行的早期标记。这些发现为FEDN MDD患者特异性视觉皮质缺陷提供了新的见解。局限性：目前的研究缺乏影像数据来支持我们观察到的感知现象。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Depression and Anxiety 医学-精神病学

CiteScore

15.00

自引率

1.40%

发文量

审稿时长

4-8 weeks

期刊介绍： Depression and Anxiety is a scientific journal that focuses on the study of mood and anxiety disorders, as well as related phenomena in humans. The journal is dedicated to publishing high-quality research and review articles that contribute to the understanding and treatment of these conditions. The journal places a particular emphasis on articles that contribute to the clinical evaluation and care of individuals affected by mood and anxiety disorders. It prioritizes the publication of treatment-related research and review papers, as well as those that present novel findings that can directly impact clinical practice. The journal's goal is to advance the field by disseminating knowledge that can lead to better diagnosis, treatment, and management of these disorders, ultimately improving the quality of life for those who suffer from them.