Maternal time interval between menarche and childbirth is associated with daughter's age at menarche

IF 3.5 2区 医学 Q1 OBSTETRICS & GYNECOLOGY
Mari Landås Warp, Thea Grindstad, Karoline H. Skåra, Maria C. Magnus, Siri E. Håberg, Nils-Halvdan Morken, Liv Bente Romundstad, Cecilia H. Ramlau-Hansen, Hans Ivar Hanevik
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Abstract

Introduction

Women's reproductive lifespan has increased over the past two decades. Simultaneously, female reproductive behavior has changed, with increasing age at first birth. Early menarche has been associated with adverse health outcomes, but research investigating the association between maternal age at childbirth and daughter's age at menarche is, so far, inconclusive. Whether the interval between menarche and childbirth or between childbirth and menopause among mothers is associated with age at menarche in daughters is not known.

Material and Methods

We conducted a cohort study with retrospectively collected data including mothers and daughters participating in the Norwegian Mother, Father and Child Cohort Study. Within this cohort, we identified two study populations. First, we included 14 576 mother-daughter pairs with complete information on maternal age at menarche and childbirth and the daughter's age at menarche. Second, we included 1350 mother-daughter pairs with complete information on maternal age at childbirth and natural menopause, and daughter's age at menarche. We calculated odds ratios (OR) with 95% confidence intervals (CIs) in a discrete survival analysis for daughters' age at menarche by time intervals from menarche to childbirth or from childbirth to menopause in mothers. We adjusted for relevant covariates.

Results

We found 5% lower yearly odds (partially adjusted OR 0.95 (CI 0.90–0.99)) of reaching menarche among daughters born by mothers <16 years after menarche compared to the reference category born 16–20 years following menarche. After additionally adjusting for maternal birth year, the effect estimate was further reduced (fully adjusted OR 0.79 (CI 0.74–0.84)). Among daughters born by mothers >20 years after menarche, the likelihood of early menarche was higher (fully adjusted OR 1.19 (CI 1.13–1.27)) compared to the reference category. Regarding the childbirth-menopause interval, our findings did not reach statistical significance in either of our models.

Conclusions

Daughters born to mothers with a shorter time interval (<16 years) between menarche and childbirth have a lower likelihood of experiencing early menarche compared to the reference category (16–20 years), and daughters born to mothers with a longer time interval from menarche to childbirth (>20 years) have a higher likelihood of reaching early menarche.

Abstract Image

母亲月经初潮与分娩的时间间隔与女儿月经初潮的年龄有关
在过去的二十年中,女性的生育寿命增加了。与此同时,女性的生育行为也随着第一胎年龄的增加而改变。月经初潮早与不利的健康结果有关,但迄今为止,调查产妇分娩年龄与女儿月经初潮年龄之间关系的研究尚无定论。母亲的月经初潮与分娩之间或分娩与绝经之间的间隔是否与女儿的月经初潮年龄有关尚不清楚。材料和方法我们进行了一项队列研究,回顾性收集了参与挪威母亲、父亲和儿童队列研究的母亲和女儿的数据。在这个队列中,我们确定了两个研究人群。首先,我们纳入了14576对母女,并提供了母亲初潮和分娩年龄以及女儿初潮年龄的完整信息。其次,我们纳入了1350对母女,并提供了母亲分娩年龄、自然绝经年龄和女儿初潮年龄的完整信息。在离散生存分析中,我们用95%可信区间(CIs)计算了女儿初潮年龄从初潮到分娩或母亲从分娩到更年期的时间间隔的比值比(OR)。我们调整了相关的协变量。结果我们发现,与初潮后16 - 20年出生的参考组相比,初潮后16年出生的母亲的女儿达到初潮的年几率(部分校正OR 0.95 (CI 0.90-0.99))降低5%。在对产妇出生年份进行额外调整后,效果估计值进一步降低(完全调整OR 0.79 (CI 0.74-0.84))。在初潮20年后母亲所生的女儿中,与参考组相比,初潮提前的可能性更高(完全校正OR 1.19 (CI 1.13-1.27))。关于分娩-绝经间隔,我们的发现在我们的模型中都没有达到统计学意义。结论初潮至分娩间隔时间较短(16年)的母亲所生女儿初潮早的可能性低于参照组(16 - 20年),初潮至分娩间隔时间较长(20年)的母亲所生女儿初潮早的可能性较高。
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来源期刊
CiteScore
8.00
自引率
4.70%
发文量
180
审稿时长
3-6 weeks
期刊介绍: Published monthly, Acta Obstetricia et Gynecologica Scandinavica is an international journal dedicated to providing the very latest information on the results of both clinical, basic and translational research work related to all aspects of women’s health from around the globe. The journal regularly publishes commentaries, reviews, and original articles on a wide variety of topics including: gynecology, pregnancy, birth, female urology, gynecologic oncology, fertility and reproductive biology.
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