Synthesis of phenothiazine lead chloride perovskite quantum dots for fluorescence detection of dipicolinic acid in aqueous medium

IF 5.3 2区化学 Q1 CHEMISTRY, ANALYTICAL

Microchimica Acta Pub Date : 2025-05-20 DOI:10.1007/s00604-025-07215-9

Nirav Vajubhai Ghinaiya, Mayurkumar Revabhai Patel, Tae Jung Park, Suresh Kumar Kailasa

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引用次数: 0

Abstract

Water-dispersible hybrid organic–inorganic perovskite quantum dots (QDs) were synthesized using phenothiazine (PTZ) as a capping agent. The PTZ capped lead chloride perovskite ((PTZ)PbCl₃ QDs) acted as a probe for the fluorescence detection of dipicolinic acid (DPA) via a fluorescence “turn-off” mechanism. This work illustrates that (PTZ)PbCl₃ QDs have strong affinity toward DPA, favoring to achieve a good linear range (5.0–40 μM) with a detection limit of 46.55 nM. Additionally, a portable (PTZ)PbCl₃ QDs integrated paper-based analytical sensing device was fabricated for fluorescence readout assay of DPA, revealing its potential for assaying of DPA with simplified analytical procedure. Furthermore, the developed (PTZ)PbCl₃ QDs integrated fluorescence spectrometric method was successfully applied to assay DPA in human serum samples. This approach serves as a promising analytical platform for detecting DPA in biofluids, offering a simple and efficient analytical sensing method for real sample analysis.

Graphical Abstract

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氯代吩噻嗪型钙钛矿量子点的合成及其荧光检测双吡啶酸的研究

以吩噻嗪（PTZ）为封盖剂，合成了水分散型有机-无机钙钛矿杂化量子点（QDs）。PTZ包封的氯化铅钙钛矿（PTZ）PbCl3量子点作为探针，通过荧光“关闭”机制对二吡啶酸（DPA）进行荧光检测。该研究表明，（PTZ）PbCl3量子点对DPA具有较强的亲和力，有利于实现良好的线性范围（5.0-40 μM），检测限为46.55 nM。此外，制作了便携式（PTZ）PbCl3量子点集成纸基分析传感装置，用于DPA的荧光读出分析，揭示了其简化分析过程的潜力。此外，所建立的PbCl3量子点集成荧光光谱法成功地应用于测定人血清样品中的DPA。该方法为生物体液中DPA的检测提供了一种简单、高效的分析传感方法。图形抽象

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来源期刊

Microchimica Acta 化学-分析化学

CiteScore

9.80

自引率

5.30%

发文量

410

审稿时长

2.7 months

期刊介绍： As a peer-reviewed journal for analytical sciences and technologies on the micro- and nanoscale, Microchimica Acta has established itself as a premier forum for truly novel approaches in chemical and biochemical analysis. Coverage includes methods and devices that provide expedient solutions to the most contemporary demands in this area. Examples are point-of-care technologies, wearable (bio)sensors, in-vivo-monitoring, micro/nanomotors and materials based on synthetic biology as well as biomedical imaging and targeting.