{"title":"Tablet Color Changes Due to Light Irradiation and Titanium Dioxide: Color Change Prevention Using Plasticizers","authors":"Yuki Matsushima, Reo Kainuma, Hidemasa Katsumi, Akiko Tanaka, Tomoyuki Furubayashi, Toshiyasu Sakane","doi":"10.1208/s12249-025-03132-5","DOIUrl":null,"url":null,"abstract":"<div><p>The color and shape of the tablets manufactured by pharmaceutical companies were selected with branding and anti-counterfeiting measures in mind. Our previous report clarified that the discoloration of tablets by light exposure is due to the degradation of hydroxypropyl methylcellulose in the coating film and that the degradation reaction is triggered by TiO<sub>2</sub>. In this study, we identified a pharmaceutical excipient that prevents light-induced discoloration of the coating film mediated by TiO<sub>2</sub>. Among the excipients examined, triethyl citrate and glycerol triacetate, which are used as plasticizers, prevented color changes in the tablets. The prevention of color change was attributed to increased tensile strength rather than the coating film's glassy or rubbery state. In conclusion, the color change of tablets owing to photochemical reactions with TiO2 can be prevented by using excipients which can increase the strength of the coating film.</p><h3>Graphical Abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":6925,"journal":{"name":"AAPS PharmSciTech","volume":"26 5","pages":""},"PeriodicalIF":3.4000,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"AAPS PharmSciTech","FirstCategoryId":"3","ListUrlMain":"https://link.springer.com/article/10.1208/s12249-025-03132-5","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
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Abstract
The color and shape of the tablets manufactured by pharmaceutical companies were selected with branding and anti-counterfeiting measures in mind. Our previous report clarified that the discoloration of tablets by light exposure is due to the degradation of hydroxypropyl methylcellulose in the coating film and that the degradation reaction is triggered by TiO2. In this study, we identified a pharmaceutical excipient that prevents light-induced discoloration of the coating film mediated by TiO2. Among the excipients examined, triethyl citrate and glycerol triacetate, which are used as plasticizers, prevented color changes in the tablets. The prevention of color change was attributed to increased tensile strength rather than the coating film's glassy or rubbery state. In conclusion, the color change of tablets owing to photochemical reactions with TiO2 can be prevented by using excipients which can increase the strength of the coating film.
期刊介绍：
AAPS PharmSciTech is a peer-reviewed, online-only journal committed to serving those pharmaceutical scientists and engineers interested in the research, development, and evaluation of pharmaceutical dosage forms and delivery systems, including drugs derived from biotechnology and the manufacturing science pertaining to the commercialization of such dosage forms. Because of its electronic nature, AAPS PharmSciTech aspires to utilize evolving electronic technology to enable faster and diverse mechanisms of information delivery to its readership. Submission of uninvited expert reviews and research articles are welcomed.
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