Successful long-term survival following lipiodol chemoembolization for hepatocellular carcinoma in Alagille syndrome: A case report

Q4 Medicine

Radiology Case Reports Pub Date : 2025-05-20 DOI:10.1016/j.radcr.2025.04.125

Imad Akasbi MD , Ismail Chaouche MD , Nizar El Bouardi MD , Amal Akammar MD , Hajar O Chahdi MD , Ismail Zerrari MD , Maria Lahlali MD , Hakima Abid MD , Badr Alami MD , Nada Lahmidani MD , Meryem Boubbou MD , Ibrahimi Sidi adil MD , Mustapha Maaroufi MD , MY Youssef Alaoui Lamrani MD

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引用次数: 0

Abstract

Alagille syndrome is a rare genetic disorder causing multisystem complications, including biliary abnormalities, chronic liver disease, and rarely, hepatocellular carcinoma (HCC), which is difficult to manage due to liver dysfunction and vascular abnormalities. We report a 29-year-old female, diagnosed with Alagille syndrome in infancy, who developed infiltrative HCC at age 20 and underwent lipiodol-based transarterial chemoembolization (TACE) in 2015, with a second session in 2016 for recurrence. Remarkably, she has achieved an exceptional 9-year survival post-treatment with stable imaging and no recurrence, a highly uncommon outcome for HCC in Alagille syndrome, highlighting TACE’s potential as an effective palliative treatment for HCC in Alagille syndrome, particularly for patient's ineligible for liver transplantation, and underscoring the need for further studies on locoregional therapies in this rare population.

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脂醇化疗栓塞治疗肝细胞癌Alagille综合征后成功的长期生存：1例报告

Alagille综合征是一种罕见的遗传性疾病，可引起多系统并发症，包括胆道异常、慢性肝脏疾病，以及罕见的肝细胞癌（HCC），由于肝功能障碍和血管异常，HCC难以治疗。我们报告了一名29岁的女性，在婴儿期被诊断为Alagille综合征，她在20岁时出现浸润性HCC，并于2015年接受了基于脂醇的经动脉化疗栓塞（TACE），并于2016年进行了第二次复发。值得注意的是，她在治疗后获得了9年的生存期，影像稳定，没有复发，这是Alagille综合征HCC的一个非常罕见的结果，突出了TACE作为Alagille综合征HCC有效姑息治疗的潜力，特别是对于不符合肝移植条件的患者，并强调了进一步研究这一罕见人群的局部治疗的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Radiology Case Reports Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

1.10

自引率

0.00%

发文量

1074

审稿时长

30 days

期刊介绍： The content of this journal is exclusively case reports that feature diagnostic imaging. Categories in which case reports can be placed include the musculoskeletal system, spine, central nervous system, head and neck, cardiovascular, chest, gastrointestinal, genitourinary, multisystem, pediatric, emergency, women''s imaging, oncologic, normal variants, medical devices, foreign bodies, interventional radiology, nuclear medicine, molecular imaging, ultrasonography, imaging artifacts, forensic, anthropological, and medical-legal. Articles must be well-documented and include a review of the appropriate literature.