Usutu virus-disease susceptibility in threatened red-breasted geese (Branta ruficollis) in Italy and the Netherlands

IF 0.8 4区农林科学 Q4 PATHOLOGY

Journal of Comparative Pathology Pub Date : 2025-05-01 DOI:10.1016/j.jcpa.2025.05.004

Giuseppe Giglia , Emmanuelle Münger , Giulia Mencattelli , Gianfilippo Agliani , Alinda J. Berends , Fabrizia Valleriani , Giorgio Filipponi , Stefano Gavaudan , Annapia Di Gennaro , Christine Fast , Reina S. Sikkema , Marja Kik , Marion P.G. Koopmans , Maria T. Mandara , Andrea Gröne , Bas B. Oude Munnink , Judith M.A. van den Brand , Chantal B.E.M. Reusken , Federica Monaco , Giovanni Savini

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引用次数: 0

Abstract

Usutu virus (USUV) is an emerging zoonotic virus associated with mortality in birds. More than 90 species of birds have been found to be susceptible to USUV infection, but little is known about the disease susceptibility and distribution in Anseriformes. This study involved the post-mortem evaluation of four threatened red-breasted geese (Branta ruficollis). Macroscopic analysis, histology, immunohistochemistry, reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and phylogenetic analysis of USUV strains were performed to evaluate the presence of USUV-associated damage, tissue tropism and involved virus strains. Macroscopic and histological lesions, represented by necrosis and mononuclear inflammation, as well as virus pan-tissue tropism, overlapped in all cases. Unlike other species, a strong involvement of endocrine organs was observed in the red-breasted geese. Two different USUV lineages, Europe 2 (in Italy) and Europe 3 (in the Netherlands), were identified as causative agents. We now report the host disease susceptibility and describe the pathology of fatal USUV-associated disease with major neurological and endocrine involvement in four threatened red-breasted geese in Italy and in the Netherlands.

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意大利和荷兰受威胁红胸鹅（Branta ruficollis）的Usutu病毒病易感性

Usutu病毒（USUV）是一种与鸟类死亡有关的新出现的人畜共患病毒。已发现90多种鸟类对USUV易感，但对该疾病在雁形目动物中的易感性和分布知之甚少。本研究对4只濒危红胸鹅（Branta ruficollis）进行了死后评估。通过宏观分析、组织学、免疫组织化学、逆转录-定量聚合酶链反应（RT-qPCR）和系统发育分析来评估USUV菌株是否存在USUV相关损伤、组织趋向性和相关病毒株。在所有病例中，以坏死和单核炎症以及病毒泛组织性为代表的宏观和组织学病变是重叠的。与其他物种不同，在红胸鹅中观察到内分泌器官的强烈参与。两种不同的USUV谱系，欧洲2号（在意大利）和欧洲3号（在荷兰），被确定为病原体。我们现在报告了宿主疾病的易感性，并描述了在意大利和荷兰的四个受威胁的红胸鹅的致命usuv相关疾病的病理，主要涉及神经和内分泌。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Comparative Pathology 生物-病理学

CiteScore

1.60

自引率

0.00%

发文量

208

审稿时长

50 days

期刊介绍： The Journal of Comparative Pathology is an International, English language, peer-reviewed journal which publishes full length articles, short papers and review articles of high scientific quality on all aspects of the pathology of the diseases of domesticated and other vertebrate animals. Articles on human diseases are also included if they present features of special interest when viewed against the general background of vertebrate pathology.