Association of circulatory hsa-miR-146a-5p and hsa-miR-192-5p with impaired fasting glycaemia in HIV infected subjects

IF 0.5 Q4 GENETICS & HEREDITY

Human Gene Pub Date : 2025-05-01 DOI:10.1016/j.humgen.2025.201421

K. Karthik , Pratibha Misra , R. Palaniswamy , Leena Rawat , Anurodh Gupta , Bhasker Mukherjee , G. Ankita , G. Ruchira , M.K. Sibin

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Abstract

Background

hsa-miR-146a-5p and hsa-miR-192-5p were associated with pre diabetes and type 2 diabetes mellitus in HIV negative individuals. However, no study reported their expression in prediabetes condition associated with HIV infected subjects undergoing anti-retroviral therapy (ART).

Methods

Circulatory hsa-miR-146a-5p and hsa-miR-192-5p expressions were measured in HIV positive subjects undergoing ART with impaired fasting glycemia (IFG) and with normoglycemia (36 in each group).

Results

There was overexpression of hsa-miR-146a-5p and hsa-miR-192-5p in serum samples of HIV infected subjects on ART with IFG when compared to their normoglycemic counterparts. Both miRNAs showed diagnostic utility in ROC curve analysis to detect IFG in HIV positive subjects on ART.

Conclusion

Present study for the first time showed the differential expression of hsa-miR-146a-5p and hsa-miR-192-5p in IFG associated with HIV infected subjects on ART. We have also shown their diagnostic utility in these patients. However, larger cohort studies are warranted to validate the results of this pilot study.

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循环hsa-miR-146a-5p和hsa-miR-192-5p与HIV感染者空腹血糖受损的关系

背景：hsa- mir -146a-5p和hsa-miR-192-5p与HIV阴性个体的糖尿病前期和2型糖尿病相关。然而，没有研究报道它们在接受抗逆转录病毒治疗（ART）的HIV感染者的前驱糖尿病状况中的表达。方法检测空腹血糖受损（IFG）和血糖正常（每组36例）接受抗逆转录病毒治疗的HIV阳性受试者血液中hsa-miR-146a-5p和hsa-miR-192-5p的表达。结果与血糖正常的HIV感染者相比，接受IFG抗逆转录病毒治疗的HIV感染者血清样本中hsa-miR-146a-5p和hsa-miR-192-5p过表达。这两种mirna在接受抗逆转录病毒治疗的HIV阳性受试者中检测IFG的ROC曲线分析中显示出诊断效用。结论本研究首次发现hsa-miR-146a-5p和hsa-miR-192-5p在ART治疗HIV感染者IFG中存在差异表达。我们还展示了它们在这些患者中的诊断效用。然而，需要更大规模的队列研究来验证本初步研究的结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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