Enduring Mental Health in Childhood and Adolescence: Prevalence, Prediction, and Genetic Architecture.

IF 9.5 1区医学 Q1 PEDIATRICS

Journal of the American Academy of Child and Adolescent Psychiatry Pub Date : 2025-05-14 DOI:10.1016/j.jaac.2025.05.001

Hekmat Alrouh, René Pool, Christel Middeldorp, Meike Bartels

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引用次数: 0

Abstract

Objective: The concept of enduring mental health (EMH) describes a long-term state in which a person does not experience mental disorders. Most people encounter mental health issues at some point; this study investigated the prevalence, predictors, and genetic architecture of EMH across childhood.

Method: EMH status was based on longitudinal data from 18,884 Dutch twins assessed at ages 3, 5, 7, 10, and 12 for behavioral and emotional problems. Children were grouped into 3 categories: EMH, some instances of mental health problems, and many instances of mental health problems. Child- and parent-level factors including individual polygenic scores were tested for associations with these 3 categories. A twin model was used to assess the contribution of genetic and environmental factors to EMH.

Results: EMH was experienced by 37% of the sample. EMH was associated with parental low and middle education categories (relative risk [95% CI] = 0.77 [0.70-0.86] and 0.88 [0.82-0.95], respectively), child academic achievement (relative risk [95% CI] = 1.07 [1.03,1.12]), and child well-being (relative risk [95% CI] = 1.44 [1.35,1.54]) and was weakly associated with some polygenic scores. The twin model estimated that 54% of the variance in EMH was due to genetic factors.

Conclusion: EMH was observed in slightly more than a third of children. Individual differences in EMH were influenced by various sociodemographic factors, mental health-related variables, and genetic predispositions, suggesting that strategies to support EMH will likely require a comprehensive, multifaceted approach.

Study registration information: Enduring Mental Health in Childhood and Adolescence: Prevalence, Prediction, and Genetic Architecture; https://osf.io/6fnwg.

Diversity & inclusion statement: We worked to ensure sex and gender balance in the recruitment of human participants. We worked to ensure that the study questionnaires were prepared in an inclusive way. We worked to ensure race, ethnic, and/or other types of diversity in the recruitment of human participants. We actively worked to promote sex and gender balance in our author group. One or more of the authors of this paper self-identifies as a member of one or more historically underrepresented racial and/or ethnic groups in science.

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儿童和青少年的持久心理健康：患病率、预测和遗传结构。

目的：持久精神健康（EMH）的概念描述了一个人没有经历精神障碍的长期状态。由于大多数人在某些时候都会遇到心理健康问题，本研究调查了童年时期EMH的患病率、预测因素和遗传结构。方法：对18884名荷兰双胞胎在3岁、5岁、7岁、10岁和12岁时的行为和情绪问题进行了EMH状态的纵向数据评估。儿童被分为三类：EMH、一些心理健康问题（SIMHP）和许多心理健康问题（MIMHP）。包括个体多基因得分在内的儿童和父母水平因素与这三个类别的关联进行了测试。采用双胞胎模型评估遗传和环境因素对EMH的影响。结果：37%的样本存在EMH。EMH与父母教育程度相关(OR(low) =0.77[0.70-0.86]；OR（中）= 0.88[0.82-0.95])、儿童学业成绩（OR=1.07[1.03,1.12]）和儿童幸福感（OR=1.44[1.35,1.54]），且与部分多基因得分呈弱相关。双胞胎模型估计，54%的EMH差异是由遗传因素造成的。结论：EMH在三分之一以上的儿童中被观察到。EMH的个体差异受到各种社会人口因素、心理健康相关变量和遗传倾向的影响，这表明支持EMH的策略可能需要一个全面的、多方面的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the American Academy of Child and Adolescent Psychiatry 医学-精神病学

CiteScore

21.00

自引率

1.50%

发文量

1383

审稿时长

53 days

期刊介绍： The Journal of the American Academy of Child & Adolescent Psychiatry (JAACAP) is dedicated to advancing the field of child and adolescent psychiatry through the publication of original research and papers of theoretical, scientific, and clinical significance. Our primary focus is on the mental health of children, adolescents, and families. We welcome unpublished manuscripts that explore various perspectives, ranging from genetic, epidemiological, neurobiological, and psychopathological research, to cognitive, behavioral, psychodynamic, and other psychotherapeutic investigations. We also encourage submissions that delve into parent-child, interpersonal, and family research, as well as clinical and empirical studies conducted in inpatient, outpatient, consultation-liaison, and school-based settings. In addition to publishing research, we aim to promote the well-being of children and families by featuring scholarly papers on topics such as health policy, legislation, advocacy, culture, society, and service provision in relation to mental health. At JAACAP, we strive to foster collaboration and dialogue among researchers, clinicians, and policy-makers in order to enhance our understanding and approach to child and adolescent mental health.