Acute pancreatitis experimental models, advantages and disadvantages.

IF 3.7 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Genaro J Rosales-Muñoz, Verónica Souza-Arroyo, Leticia Bucio-Ortiz, Roxana U Miranda-Labra, Luis E Gomez-Quiroz, María Concepción Gutiérrez-Ruiz
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引用次数: 0

Abstract

Acute pancreatitis represents a severe health problem, not only because of the number of people affected but also because of the severity of its clinical presentation that can eventually lead to the death of patients. The study of the disease is complex, and we lack optimized models that can approach the clinical presentation in patients, in addition to the significant vulnerability of the organ itself. In the present work, we undertook the task of reviewing and analyzing the experimental methods most currently used for the induction of acute pancreatitis, emphasizing the advantages and disadvantages of each model and their delimitation based on experimental objectives. We aimed to provide an actual and quick-access guide for researchers interested in experimental acute pancreatitis.

急性胰腺炎实验模型,优缺点。
急性胰腺炎是一个严重的健康问题,不仅因为受影响的人数众多,而且还因为其临床表现的严重性,最终可能导致患者死亡。这种疾病的研究是复杂的,我们缺乏优化的模型,可以接近患者的临床表现,以及器官本身的显著脆弱性。在本工作中,我们承担了回顾和分析目前最常用的诱导急性胰腺炎的实验方法的任务,强调每种模型的优点和缺点,并根据实验目的进行划分。我们的目标是为对实验性急性胰腺炎感兴趣的研究人员提供一个实际和快速的指南。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of physiology and biochemistry
Journal of physiology and biochemistry 生物-生化与分子生物学
CiteScore
6.60
自引率
0.00%
发文量
86
审稿时长
6-12 weeks
期刊介绍: The Journal of Physiology and Biochemistry publishes original research articles and reviews describing relevant new observations on molecular, biochemical and cellular mechanisms involved in human physiology. All areas of the physiology are covered. Special emphasis is placed on the integration of those levels in the whole-organism. The Journal of Physiology and Biochemistry also welcomes articles on molecular nutrition and metabolism studies, and works related to the genomic or proteomic bases of the physiological functions. Descriptive manuscripts about physiological/biochemical processes or clinical manuscripts will not be considered. The journal will not accept manuscripts testing effects of animal or plant extracts.
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