ADHD Symptoms and Medical Cannabis Use Among Adults With Chronic Pain.

IF 2.7 3区医学 Q2 PSYCHIATRY

Journal of Attention Disorders Pub Date : 2025-05-17 DOI:10.1177/10870547251336841

David Saunders, Deepika Slawek, Chenshu Zhang, Nancy Sohler, Chinazo Cunningham, Haruka Minami, Joanna Starrels, Julia Arnsten, Frances Levin

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引用次数: 0

Abstract

Objective: We examined whether medical cannabis (MC) use was associated with change in ADHD symptoms across time in a sample of adults with chronic pain.

Methods: We conducted a longitudinal cohort study (N = 223) across 12 months, assessing ADHD symptoms and MC use. We used mixed-effects linear regression to test whether MC use (vs. no use) and high THC (vs. low THC) MC was associated with change in ADHD symptoms from baseline to follow-up at quarterly intervals. We stratified by baseline ADHD symptoms and pain catastrophizing.

Results: MC use was not associated with change in ADHD symptoms in the full sample or those with moderate/severe ADHD symptoms. Among those with minor/no baseline ADHD symptoms, high-THC MC (vs. low-THC) was associated with a decrease in ADHD symptoms.

Conclusions: The null findings among participants with moderate/severe ADHD symptoms suggests that cannabis is unlikely to be a good treatment for ADHD. The preliminary findings in those with mild ADHD symptoms should be interpreted with caution given the small sample, the modest result, and all participants had chronic pain. These results may temper enthusiasm for MC as a treatment for ADHD, but further studies in larger and more generalizable samples may be justified.

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慢性疼痛的成人ADHD症状和医用大麻的使用

目的：我们研究了医用大麻（MC）的使用是否与患有慢性疼痛的成人样本中ADHD症状的变化有关。方法：我们进行了一项为期12个月的纵向队列研究（N = 223），评估ADHD症状和MC使用情况。我们使用混合效应线性回归来检验MC使用（vs.不使用）和高THC (vs.低THC) MC是否与每季度从基线到随访期间ADHD症状的变化相关。我们根据基线ADHD症状和疼痛灾难化进行分层。结果：在整个样本中或那些有中度/重度ADHD症状的患者中，使用MC与ADHD症状的改变无关。在有轻微/无基线ADHD症状的患者中，高thc MC（相对于低thc）与ADHD症状的减轻相关。结论：在中度/重度ADHD症状的参与者中，无效发现表明大麻不太可能是ADHD的良好治疗方法。考虑到样本量小，结果一般，而且所有参与者都有慢性疼痛，对轻度多动症患者的初步研究结果应谨慎解读。这些结果可能会降低MC作为ADHD治疗方法的热情，但在更大更广泛的样本中进行进一步的研究可能是合理的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Attention Disorders PSYCHIATRY-

CiteScore

7.60

自引率

6.70%

发文量

审稿时长

6-12 weeks

期刊介绍： Journal of Attention Disorders (JAD) focuses on basic and applied science concerning attention and related functions in children, adolescents, and adults. JAD publishes articles on diagnosis, comorbidity, neuropsychological functioning, psychopharmacology, and psychosocial issues. The journal also addresses practice, policy, and theory, as well as review articles, commentaries, in-depth analyses, empirical research articles, and case presentations or program evaluations.