Interaction between asthma and overweight/obesity on cancer results from the National Health and Nutrition Examination Survey 2005-2018.

IF 2.6 3区 医学 Q2 ALLERGY
Wei Zhang, Lili Cao, Jiubo Sun, Cui Zhang
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Abstract

Background and Aims: Asthma, overweight/obesity, and cancer are closely related major public health problems. This study aimed to investigate the interaction between asthma and overweight/obesity on the cancer risk. Methods: We analyzed data from the National Health and Nutrition Examination Survey 2005-2018. Participants ages ≥ 20 years with information on asthma status, body mass index (BMI), and cancer diagnosis were included. Multivariate logistic regression models adjusted for relevant covariates were used to examine the associations among asthma, overweight/obesity, and cancer risk. In addition, we assessed the additive interaction between asthma and overweight/obesity on the cancer risk by using measures, including the relative excess risk due to interaction (RERI), attributable proportion of interaction (AP), and synergy index (S). Results: In total, 26,320 participants met the inclusion criteria. Asthma was associated with an increased risk of cancer (odds ratio [OR] 1.37 [95% confidence interval {CI}, 1.17-1.59]), whereas overweight/obesity (BMI ≥ 25 kg/m²) was also significantly associated with an elevated cancer risk (OR 1.97 [95% CI, 1.32-2.94]). Notably, a significant interaction between asthma and overweight/obesity was observed in relation to the cancer risk (RERI 0.49 [95% CI, 0.02-0.96]; AP 0.20 [95% CI, 0.04, 0.37]; S 1.53 [95% CI, 1.01-2.32]). Conclusion: Our findings demonstrated a synergistic interaction between asthma and overweight/obesity on the cancer risk. The combined effect of asthma and overweight/obesity on the cancer risk exceeded the sum of their individual effects.

2005-2018年全国健康与营养调查结果:哮喘、超重/肥胖与癌症的相互作用
背景与目的:哮喘、超重/肥胖和癌症是密切相关的主要公共卫生问题。本研究旨在探讨哮喘和超重/肥胖对癌症风险的相互作用。方法:分析2005-2018年全国健康与营养检查调查数据。受试者年龄≥20岁,哮喘状况、身体质量指数(BMI)和癌症诊断信息均被纳入研究。采用校正相关协变量的多变量logistic回归模型来检验哮喘、超重/肥胖和癌症风险之间的关系。此外,我们评估了哮喘和超重/肥胖之间的加性相互作用对癌症风险的影响,包括相互作用的相对过量风险(rei)、相互作用的归因比例(AP)和协同作用指数(S)。结果:共有26320名受试者符合纳入标准。哮喘与癌症风险增加相关(比值比[OR] 1.37[95%可信区间{CI}, 1.17-1.59]),而超重/肥胖(BMI≥25 kg/m²)也与癌症风险升高显著相关(OR 1.97 [95% CI, 1.32-2.94])。值得注意的是,哮喘和超重/肥胖之间的显著相互作用与癌症风险有关(rei 0.49 [95% CI, 0.02-0.96];Ap 0.20 [95% ci, 0.04, 0.37];S 1.53 [95% ci, 1.01-2.32])。结论:我们的研究结果表明哮喘和超重/肥胖对癌症风险有协同作用。哮喘和超重/肥胖对癌症风险的综合影响超过了它们各自影响的总和。
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来源期刊
CiteScore
5.70
自引率
35.70%
发文量
106
审稿时长
6-12 weeks
期刊介绍: Allergy & Asthma Proceedings is a peer reviewed publication dedicated to distributing timely scientific research regarding advancements in the knowledge and practice of allergy, asthma and immunology. Its primary readership consists of allergists and pulmonologists. The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma. Featured topics include asthma, rhinitis, sinusitis, food allergies, allergic skin diseases, diagnostic techniques, allergens, and treatment modalities. Published material includes peer-reviewed original research, clinical trials and review articles.
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