Emerging tools and methods to study cell signalling mediated by branched ubiquitin chains.

IF 3.8 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Matthew R McFarland, Yogesh Kulathu
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引用次数: 0

Abstract

Branched ubiquitin chains are complex molecular structures in which two or more ubiquitin moieties are attached to distinct lysine residues of a single ubiquitin molecule within a polyubiquitin chain. These bifurcated architectures significantly expand the signalling capacity of the ubiquitin system. Although branched chains constitute a substantial fraction of cellular polyubiquitin, their biological functions largely remain enigmatic due to their complex nature and the associated technical challenges of studying them. Recent technological innovations have enabled the identification of key molecular players and revealed essential roles for branched chains in diverse cellular processes. In this review, we discuss the bespoke strategies that have driven these discoveries, as well as the technologies needed to advance this rapidly evolving field.

研究分支泛素链介导的细胞信号传导的新兴工具和方法。
支化泛素链是一种复杂的分子结构,在多泛素链中,两个或多个泛素片段连接到单个泛素分子的不同赖氨酸残基上。这些分叉的结构显著地扩展了泛素系统的信号能力。尽管支链构成了细胞多泛素的很大一部分,但由于其复杂性和研究它们的相关技术挑战,它们的生物学功能在很大程度上仍然是谜。最近的技术创新使得关键分子的识别成为可能,并揭示了支链在不同细胞过程中的重要作用。在这篇综述中,我们讨论了推动这些发现的定制策略,以及推进这一快速发展领域所需的技术。
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来源期刊
Biochemical Society transactions
Biochemical Society transactions 生物-生化与分子生物学
CiteScore
7.80
自引率
0.00%
发文量
351
审稿时长
3-6 weeks
期刊介绍: Biochemical Society Transactions is the reviews journal of the Biochemical Society. Publishing concise reviews written by experts in the field, providing a timely snapshot of the latest developments across all areas of the molecular and cellular biosciences. Elevating our authors’ ideas and expertise, each review includes a perspectives section where authors offer comment on the latest advances, a glimpse of future challenges and highlighting the importance of associated research areas in far broader contexts.
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