Evaluating the diagnostic accuracy of imprint and scrape cytology for intraoperative risk stratification of ovarian tumors: A systematic review and meta-analysis

IF 2.6 3区医学 Q3 ONCOLOGY

Cancer Cytopathology Pub Date : 2025-05-19 DOI:10.1002/cncy.70024

Mishu Mangla MBBS, MS, PDCC, Seetu Palo MBBS, MD, Anusha Devalla MBBS, MS, DNB, Poojitha Kalyani Kanikaram MBBS, MD

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引用次数: 0

Abstract

Background

Accurate intraoperative assessment of ovarian tumors is crucial for guiding surgical management. The objective of this systematic review and meta-analysis was to evaluate the diagnostic accuracy of imprint and scrape cytology for intraoperative risk stratification of ovarian tumors.

Methods

A comprehensive literature search was conducted across multiple databases to identify studies that assessed the sensitivity, specificity, positive predictive value, and negative predictive value of imprint and scrape cytology in distinguishing benign and malignant ovarian tumors. Data were pooled using a bivariate random-effects model. The methodological quality of included studies was assessed using the quality assessment of diagnostic accuracy studies 2 tool.

Results

In total, 34 studies comprising 3318 ovarian tumors were included in the current review. Analysis indicated that the pooled sensitivity of imprint cytology was 89%, whereas the pooled specificity was 92%. The positive and negative likelihood ratios, calculated using a random-effects model, were 8.47 (95% confidence interval [CI], 5.27–13.61) and 0.16 (95% CI, 0.12–0.21), respectively. The pooled diagnostic odds ratio was 63.42 (95% CI, 37.5–107.27). For scrape cytology, the pooled sensitivity and specificity were 89% and 97%, respectively. The positive and negative likelihood ratios were 21.05 (95% CI, 12.36–35.84) and 0.14 (95% CI, 0.09–0.22), respectively. The pooled diagnostic odds ratio was 180.46 (95% CI, 88.01–370.03). Both techniques demonstrated high diagnostic accuracy, and scrape cytology was particularly effective in detecting malignancies.

Conclusions

Imprint and scrape cytology are valuable intraoperative diagnostic tools for ovarian tumor stratification, offering rapid and reliable results. Their integration into surgical decision making may enhance intraoperative management, particularly in resource-limited settings. Further studies with standardized protocols are needed to refine their clinical utility.

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评估印迹和刮痕细胞学对卵巢肿瘤术中风险分层的诊断准确性：一项系统回顾和荟萃分析

背景准确的术中评估卵巢肿瘤对指导手术治疗至关重要。本系统综述和荟萃分析的目的是评估印迹和刮痕细胞学对卵巢肿瘤术中危险分层的诊断准确性。方法对多个数据库进行综合文献检索，找出印迹细胞学和刮痕细胞学鉴别卵巢良恶性肿瘤的敏感性、特异性、阳性预测值和阴性预测值的研究。数据采用双变量随机效应模型汇总。使用诊断准确性研究2的质量评估工具对纳入研究的方法学质量进行评估。结果本综述共纳入34项研究，包括3318例卵巢肿瘤。分析表明，印迹细胞学的综合敏感性为89%，而综合特异性为92%。使用随机效应模型计算的正似然比和负似然比分别为8.47（95%可信区间[CI]， 5.27-13.61）和0.16 （95% CI, 0.12-0.21）。合并诊断优势比为63.42 （95% CI, 37.5-107.27）。对于刮伤细胞学，合并敏感性和特异性分别为89%和97%。阳性和阴性似然比分别为21.05 （95% CI, 12.36-35.84）和0.14 （95% CI, 0.09-0.22）。合并诊断优势比为180.46 （95% CI, 88.01-370.03）。这两种技术都显示出很高的诊断准确性，刮片细胞学在检测恶性肿瘤方面特别有效。结论印迹细胞学和刮片细胞学是卵巢肿瘤分层诊断的重要工具，诊断结果快速可靠。将它们整合到手术决策中可以加强术中管理，特别是在资源有限的情况下。需要进一步研究标准化方案，以完善其临床应用。

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来源期刊

Cancer Cytopathology 医学-病理学

CiteScore

7.00

自引率

17.60%

发文量

130

审稿时长

1 months

期刊介绍： Cancer Cytopathology provides a unique forum for interaction and dissemination of original research and educational information relevant to the practice of cytopathology and its related oncologic disciplines. The journal strives to have a positive effect on cancer prevention, early detection, diagnosis, and cure by the publication of high-quality content. The mission of Cancer Cytopathology is to present and inform readers of new applications, technological advances, cutting-edge research, novel applications of molecular techniques, and relevant review articles related to cytopathology.