Green one-step synthesis of carbon dots via waste grape seeds as fluorescent probe for detection of folic acid in biological samples

IF 5.5 3区材料科学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Carbon Letters Pub Date : 2025-02-15 DOI:10.1007/s42823-025-00875-w

Lixin Ding, Na Sun, He Zuo, Fang Luan, Lin Hou, Zhiyou Chen, Xue Sun, Yuting Zheng, Zongyu Dai, Yuguang Lv, Xingyu Hou

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Abstract

Waste utilization is not only a way to protect the environment and realize green chemistry, but also a means to create novel materials. In this study, based on waste grape seeds as the biowaste-derived carbon dots (G-BCDs), a straightforward one-pot green method was employed for the rapid detection of folic acid (FA). Owing to the internal filter effect and the static mixing quenching mechanism, the sensing principle of G-BCDs was effectively quenched by FA. The results showed fluorescence at an emission wavelength of 415 nm upon excitation at 330 nm with a quantum yield of 1.5%. Particularly, the FA sensing assay obtained a broad linear range of 2–220 μM and the limit of detection was 0.48 μM. In addition, the fluorescence probe was successfully utilized for detecting FA in tablets, blood, and urine samples, yielding desirable results, which indicated promising applications in the fields of biological and pharmaceutical analysis.

Graphical abstract

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利用废葡萄籽一步合成碳点荧光探针检测生物样品中叶酸

废物利用不仅是保护环境、实现绿色化学的途径，也是创造新型材料的手段。本研究以废弃葡萄籽为原料，采用一锅绿法快速检测叶酸（FA）。由于内部过滤效应和静态混合淬火机制，G-BCDs的传感原理被FA有效地淬火。结果表明，在330 nm激发下，荧光发射波长为415 nm，量子产率为1.5%。在2 ~ 220 μM的宽线性范围内，检测限为0.48 μM。此外，荧光探针已成功地用于检测片剂、血液和尿液样品中的FA，取得了理想的结果，这表明在生物和药物分析领域有广阔的应用前景。图形抽象

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来源期刊

Carbon Letters CHEMISTRY, MULTIDISCIPLINARY-MATERIALS SCIENCE, MULTIDISCIPLINARY

CiteScore

7.30

自引率

20.00%

发文量

118

期刊介绍： Carbon Letters aims to be a comprehensive journal with complete coverage of carbon materials and carbon-rich molecules. These materials range from, but are not limited to, diamond and graphite through chars, semicokes, mesophase substances, carbon fibers, carbon nanotubes, graphenes, carbon blacks, activated carbons, pyrolytic carbons, glass-like carbons, etc. Papers on the secondary production of new carbon and composite materials from the above mentioned various carbons are within the scope of the journal. Papers on organic substances, including coals, will be considered only if the research has close relation to the resulting carbon materials. Carbon Letters also seeks to keep abreast of new developments in their specialist fields and to unite in finding alternative energy solutions to current issues such as the greenhouse effect and the depletion of the ozone layer. The renewable energy basics, energy storage and conversion, solar energy, wind energy, water energy, nuclear energy, biomass energy, hydrogen production technology, and other clean energy technologies are also within the scope of the journal. Carbon Letters invites original reports of fundamental research in all branches of the theory and practice of carbon science and technology.