Chitosan-wrapped MOF-808 surface for amplifying electrochemical chiral recognition signal

IF 5.3 2区化学 Q1 CHEMISTRY, ANALYTICAL

Microchimica Acta Pub Date : 2025-05-19 DOI:10.1007/s00604-025-07206-w

Xiaohui Niu, Zhe Wang, Xing Yang, Hongxia Li, Kunjie Wang

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引用次数: 0

Abstract

Metal–organic frameworks (MOFs) have unique structural and physicochemical properties and show broad application potential in the field of electrocatalysis. However, the organic building blocks of traditional MOFs usually come from non-renewable raw materials, and their inherent toxicity and non-biodegradability limit their application in the field of biocatalysis. By doping with natural polysaccharides, this new type of MOFs not only endows the material with biocompatibility and flexibility, but also provides a new dimension for regulating its catalytic performance. In this work, chitosan is combined with the synthesized MOF-808 through hydrogen bonding, so that chitosan is gradually coated on the surface of MOF-808 or fills part of its pores to form a composite material (MOF-808@CS). This composite structure is constantly adjusted and improved, making the interaction between chitosan and MOF-808 more uniform and stable and ultimately forming a relatively stable MOF-808@CS composite material. The enantioselective detection of tryptophan enantiomers by MOF-808@CS was demonstrated by electrochemical testing. The MOF-808@CS material can be used for enantiomer recognition. It is worth noting that this new type of polysaccharide-functionalized MOFs has important application potential in the field of asymmetric catalysis and provides a new research direction for green catalysis and biocatalysis.

Graphical Abstract

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壳聚糖包裹MOF-808表面放大电化学手性识别信号

金属有机骨架具有独特的结构和物理化学性质，在电催化领域具有广阔的应用前景。然而，传统mof的有机组成部分通常来自不可再生原料，其固有的毒性和不可生物降解性限制了其在生物催化领域的应用。通过掺入天然多糖，这种新型mof材料不仅具有生物相容性和柔韧性，而且为调节其催化性能提供了一个新的维度。在这项工作中，壳聚糖通过氢键与合成的MOF-808结合，使壳聚糖逐渐涂覆在MOF-808表面或填充其部分孔隙，形成复合材料（MOF-808@CS）。这种复合结构不断调整和完善，使壳聚糖与MOF-808的相互作用更加均匀稳定，最终形成相对稳定的MOF-808@CS复合材料。通过电化学实验证明了MOF-808@CS对色氨酸对映体的选择性检测。MOF-808@CS材料可用于对映体识别。值得注意的是，这种新型多糖功能化MOFs在不对称催化领域具有重要的应用潜力，为绿色催化和生物催化提供了新的研究方向。图形抽象

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来源期刊

Microchimica Acta 化学-分析化学

CiteScore

9.80

自引率

5.30%

发文量

410

审稿时长

2.7 months

期刊介绍： As a peer-reviewed journal for analytical sciences and technologies on the micro- and nanoscale, Microchimica Acta has established itself as a premier forum for truly novel approaches in chemical and biochemical analysis. Coverage includes methods and devices that provide expedient solutions to the most contemporary demands in this area. Examples are point-of-care technologies, wearable (bio)sensors, in-vivo-monitoring, micro/nanomotors and materials based on synthetic biology as well as biomedical imaging and targeting.