Synergistic coupling of ultrasonic cavitation with tailored deep eutectic solvent systems for intensified extraction of Scutellaria Radix flavonoids: Modelling and optimization by genetic algorithm

IF 8.7 1区化学 Q1 ACOUSTICS

Ultrasonics Sonochemistry Pub Date : 2025-05-15 DOI:10.1016/j.ultsonch.2025.107386

Qi Cui , Jia-Yi Shi , Le-Le Wen , Wei-Hua Kong, Li-Jie Jiang, Ju-Zhao Liu

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引用次数: 0

Abstract

Deep eutectic solvents (DESs) are increasingly recognized as viable environmentally friendly alternatives to traditional organic solvents because of their low toxicity and exceptional dissolving capabilities. In this research, 12 DESs were synthesized and systematically integrated with ultrasonic-assisted extraction (UAE) to extract flavonoids from Scutellaria Radix. Comprehensive screening revealed that the optimal DES outperformed conventional solvents (water and 70 % ethanol) in extraction efficiency. Through statistical optimization, including single-factor experiments, response surface methodology, and an artificial neural network–genetic algorithm, we achieved remarkable extraction yields for six target flavonoids: scutellarin (3.88 ± 0.37), baicalin (137.67 ± 8.61), wogonoside (13.40 ± 0.58), baicalein (27.95 ± 1.12), wogonin (15.95 ± 1.48), and chrysin (1.81 ± 0.21 mg/g). These values represented significant improvements over conventional extraction methods. Subsequent enrichment processes yielded flavonoid recovery rates of 76.80–85.13 %, and demonstrated excellent DES recyclability over four consecutive extraction cycles. In sum, this work establishes a sustainable, high-efficiency platform for phytochemical extraction, offering substantial advances in sustainable natural product processing through intelligent solvent design and process optimization.

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超声空化与深度共晶溶剂体系协同耦合强化提取黄芩黄酮：遗传算法建模与优化

深共晶溶剂（DESs）由于其低毒性和优异的溶解能力，越来越被认为是传统有机溶剂的可行的环保替代品。本研究合成了12种DESs，并与超声辅助提取法（UAE）系统结合提取黄芩中的黄酮类化合物。综合筛选表明，最优的DES萃取效率优于常规溶剂（水和70%乙醇）。通过单因素实验、响应面法和人工神经网络遗传算法等统计优化，获得了黄芩苷（3.88±0.37）、黄芩苷（137.67±8.61）、黄芩苷（13.40±0.58）、黄芩苷（27.95±1.12）、黄芩苷（15.95±1.48）、黄菊花素（1.81±0.21）mg/g的提取率。这些数值与传统的提取方法相比有了显著的改进。随后的富集工艺中，黄酮类化合物的回收率为76.80 ~ 85.13%，并且在连续4次提取循环中表现出良好的DES可回收性。总之，本研究建立了一个可持续的、高效的植物化学提取平台，通过智能溶剂设计和工艺优化，为可持续的天然产物加工提供了实质性的进展。

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来源期刊

Ultrasonics Sonochemistry 化学-化学综合

CiteScore

15.80

自引率

11.90%

发文量

361

审稿时长

59 days

期刊介绍： Ultrasonics Sonochemistry stands as a premier international journal dedicated to the publication of high-quality research articles primarily focusing on chemical reactions and reactors induced by ultrasonic waves, known as sonochemistry. Beyond chemical reactions, the journal also welcomes contributions related to cavitation-induced events and processing, including sonoluminescence, and the transformation of materials on chemical, physical, and biological levels. Since its inception in 1994, Ultrasonics Sonochemistry has consistently maintained a top ranking in the "Acoustics" category, reflecting its esteemed reputation in the field. The journal publishes exceptional papers covering various areas of ultrasonics and sonochemistry. Its contributions are highly regarded by both academia and industry stakeholders, demonstrating its relevance and impact in advancing research and innovation.