Base-promoted hydrophosphination of in situ formed aza-ortho-quinone methides for the preparation of 2-aminobenzyl phosphorus oxides

Abstract

A base-promoted 1,4-hydrophosphination of in situ generated aza-ortho-quinone methides (aza-o-QMs) from N-(ortho-chloromethyl)aryl amides was reported in this work. Diarylphosphine oxides and phosphites serve as efficient P-nucleophiles in these reactions. The advantages of this method include a broad substrate scope, operational simplicity, mild conditions, and high yields, providing an alternative strategy for synthesizing various 2-aminobenzyl phosphorus oxides.