Paul Feuerstadt , Mei Lu , Emi Terasawa , Brian Terreri , Shawn Du , Selina Pi , Ben Westermeyer , Rajeev Ayyagari , Anthony Lembo , Baharak Moshiree , Mena Boules , Brooks D. Cash
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引用次数: 0
Abstract
Background and Aims
Chronic idiopathic constipation (CIC) is associated with substantial health care resource utilization (HCRU) and economic burden; however, real-world evidence on the impact of treatment initiation on HCRU and health care costs are limited. We evaluated HCRU and direct health care costs associated with prucalopride initiation in patients with CIC in the United States.
Methods
Data were collected between January 1, 2015, and June 30, 2020, from the IBM MarketScan Commercial Claims and Encounters and Medicare Supplemental Databases for 690 adults with ≥ 1 prescription fill for prucalopride and ≥ 1 constipation-related diagnosis code. All-cause and constipation-related HCRU (outpatient, emergency room, and inpatient visits) for all patients, and pharmacy and medical health care costs for those aged 18–64 years were assessed 6 months before (baseline) and after (study period) prucalopride initiation. Subpopulations examined were patients with prior CIC medication use and males with CIC.
Results
Compared with baseline, the mean number of any constipation-related outpatient visits (2.26 vs 1.52; P < .001) and the proportions of patients with these visits (82.6% vs 58.8%; P < .001) significantly decreased after prucalopride initiation. In 564 patients, total constipation-related health care costs significantly increased from baseline during the study period (mean: $1497 vs $2332; P < .001), primarily driven by increased pharmacy costs after prucalopride initiation ($621 vs $1751; P < .001). Constipation-related medical costs significantly decreased during the study period ($876 vs $580; P < .001). Some constipation-related HCRU and health care costs decreased after prucalopride initiation in patients with prior CIC medication use and males.
Conclusion
In adults with CIC, constipation-related HCRU and medical costs decreased, while constipation-related health care costs and pharmacy costs increased 6 months after prucalopride initiation.