The effects of Zn and Sr Co-doping on local structure, dielectric properties, and bioactivity of hydroxyapatite porous materials

IF 2.8 3区物理与天体物理 Q3 CHEMISTRY, PHYSICAL

Radiation Physics and Chemistry Pub Date : 2025-05-12 DOI:10.1016/j.radphyschem.2025.112928

Arthit Ruttakorn , Siriwan Tocho , Rattikorn Yimnirun , Thanit Saisopa , Tanachat Eknapakul , Prae Chirawatkul , Russameeruk Noonurak , Atipong Bootchanont

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引用次数: 0

Abstract

Hydroxyapatite (HA) is a vital biomaterial widely used in bone implants and orthodontics due to its excellent biocompatibility. In this study, Sr and Zn co-doped HA was synthesized using the sol-gel combustion method and cast into porous materials. Samples containing 5 mol% Sr and varying Zn concentrations (0, 1, 3, and 5 mol%) were labeled as 0ZnSr-HA, 1ZnSr-HA, 3ZnSr-HA, and 5ZnSr-HA, respectively. The crystal and local structures were analyzed using X-ray diffraction (XRD) and X-ray absorption near-edge structure (XANES), revealing that Zn²⁺ and Sr²⁺ ions substitute at the Ca1 and Ca2 sites within the hydroxyapatite lattice. The dielectric properties were investigated over a frequency range of 20–10³ Hz, where 3ZnSr-HA exhibited the highest dielectric constant of 39.74, suggesting its potential to support bone growth during simulated body fluid (SBF) testing. The microstructure and elemental composition of the samples were examined using scanning electron microscopy (SEM) and energy-dispersive X-ray analysis (EDX). After 2 weeks of immersion in SBF, 3ZnSr-HA demonstrated significant apatite growth, highlighting the ability of Zn and Sr co-substitution to enhance the HA structure and improve bone regeneration efficiency. This study confirms the potential of Sr- and Zn-doped HA as a promising material for biomedical applications.

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Zn和Sr共掺杂对羟基磷灰石多孔材料局部结构、介电性能和生物活性的影响

羟基磷灰石（Hydroxyapatite， HA）具有良好的生物相容性，是一种重要的生物材料，广泛应用于骨种植体和正畸治疗。本研究采用溶胶-凝胶燃烧法合成了Sr和Zn共掺杂的透明质酸，并将其浇铸到多孔材料中。含有5 mol% Sr和不同Zn浓度（0、1、3和5 mol%）的样品分别标记为0znssr - ha、1znssr - ha、3znssr - ha和5znssr - ha。利用x射线衍射（XRD）和x射线吸收近边结构（XANES）分析了晶体结构和局部结构，发现Zn2+和Sr2+离子在羟基磷灰石晶格内的Ca1和Ca2位点上替代。在20-103 Hz的频率范围内研究了介电性能，其中3ZnSr-HA的介电常数最高，为39.74，表明其在模拟体液（SBF）测试中具有支持骨生长的潜力。采用扫描电子显微镜（SEM）和能量色散x射线分析（EDX）对样品的微观结构和元素组成进行了研究。在SBF中浸泡2周后，3znssr -HA显示出明显的磷灰石生长，表明Zn和Sr共取代增强HA结构和提高骨再生效率的能力。这项研究证实了锶和锌掺杂透明质酸作为一种有前途的生物医学应用材料的潜力。

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来源期刊

Radiation Physics and Chemistry 化学-核科学技术

CiteScore

5.60

自引率

17.20%

发文量

574

审稿时长

12 weeks

期刊介绍： Radiation Physics and Chemistry is a multidisciplinary journal that provides a medium for publication of substantial and original papers, reviews, and short communications which focus on research and developments involving ionizing radiation in radiation physics, radiation chemistry and radiation processing. The journal aims to publish papers with significance to an international audience, containing substantial novelty and scientific impact. The Editors reserve the rights to reject, with or without external review, papers that do not meet these criteria. This could include papers that are very similar to previous publications, only with changed target substrates, employed materials, analyzed sites and experimental methods, report results without presenting new insights and/or hypothesis testing, or do not focus on the radiation effects.