Electrocardiography-derived autonomic profiles in depression and suicide risk with insights from the UK Biobank.

Samantha Weber, Mario Müller, Golo Kronenberg, Erich Seifritz, Vladeta Ajdacic-Gross, Sebastian Olbrich
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Abstract

The role of the autonomic nervous system (ANS) in depression and suicidality is multifaceted. This study examined whether distinct electrocardiography based ANS profiles exist, associated with a lifetime/recent at-risk cohort or a resilient group. Using data from 15,768 participants from the UK Biobank, four unique ANS activity patterns related to heart rate variability (HRV) measures were identified. Two specific clusters, both with low HRV, showed different risks: one characterized by high relative sympathetic tonus and lower breathing rate, indicated higher resilience with less likely depressive symptoms and suicidal thoughts whereas another cluster with dominant relative parasympathetic activity and high breathing rate, aligned with greater depression and suicide attempt prevalence, potentially representing a high-risk cluster. Resilience to depression might be defined by different psychophysiological entities and coping strategies, where the resilient cluster might be characterized by cognitive coping strategies, and increased susceptibility might be linked to more rigid maladaptive coping strategies.

来自英国生物银行的见解在抑郁症和自杀风险中的心电图衍生的自主神经谱。
自主神经系统(ANS)在抑郁和自杀中的作用是多方面的。本研究调查了基于心电图的ANS特征是否存在,是否与终生/近期有风险的队列或弹性组相关。使用来自英国生物银行的15768名参与者的数据,确定了与心率变异性(HRV)测量相关的四种独特的ANS活动模式。两组HRV均较低的特定组表现出不同的风险:一组以相对交感神经张力高和呼吸频率低为特征,表明恢复力较高,抑郁症状和自杀念头较少;另一组以相对副交感神经活动占主导地位,呼吸频率高,抑郁和自杀企图发生率较高,可能代表高风险组。抗抑郁能力可能由不同的心理生理实体和应对策略来定义,其中抗抑郁能力集群可能以认知应对策略为特征,而易感性的增加可能与更严格的适应不良应对策略有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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