Postdiagnosis Smoking Cessation and Survival Outcomes of Head and Neck Cancer Patients.

IF 2.3 3区医学 Q1 OTORHINOLARYNGOLOGY

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2025-05-15 DOI:10.1002/hed.28182

Elham Mohebbi, Garret Guthrie, Siddhi Patil, William Benjamin, Ming Tan, Jonathan P Giurintano, Matthew E Witek, Peter H Ahn, Kathryn Taylor, Gregory Wolf, Ruzong Fan, Laura S Rozek

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引用次数: 0

Abstract

Background: Post-diagnosis smoking remains prevalent among head and neck squamous cell carcinoma (HNSCC) patients. Smoking cessation may improve patient outcomes.

Methods: A prospective longitudinal cohort study (2008-2014) included 835 newly diagnosed HNSCC patients and followed up for 7 years. Participants were categorized by smoking behavior (never smokers, former smokers, quitters, continuing smokers, and intermittent smokers). The primary outcomes were overall survival (OS) and recurrence-free survival (RFS).

Results: Smoking cessation after diagnosis was associated with significantly improved OS. Quitters had a 61% reduction in mortality risk compared to continuing smokers (HR: 0.39, 95% CI: 0.22, 0.69), with the greatest benefit in oral cavity cancer patients (HR: 0.28, 95% CI: 0.12, 0.65). Intermittent smokers also showed improved survival (HR: 0.50, 95% CI: 0.31, 0.79). RFS did not significantly differ based on smoking behavior.

Conclusions: Smoking cessation post-diagnosis improves OS, particularly in oral cavity cancer patients, highlighting the importance of targeted smoking cessation interventions in HNSCC care.

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头颈癌患者诊断后戒烟与生存结局。

背景：诊断后吸烟在头颈部鳞状细胞癌（HNSCC）患者中仍然普遍存在。戒烟可以改善病人的预后。方法：采用前瞻性纵向队列研究（2008-2014），纳入835例新诊断的HNSCC患者，随访7年。参与者按吸烟行为分类（从不吸烟者、曾经吸烟者、戒烟者、持续吸烟者和间歇性吸烟者）。主要结局是总生存期（OS）和无复发生存期（RFS）。结果：诊断后戒烟与OS显著改善相关。与持续吸烟者相比，戒烟者的死亡风险降低了61% (HR: 0.39, 95% CI: 0.22, 0.69)，口腔癌患者获益最大（HR: 0.28, 95% CI: 0.12, 0.65）。间歇性吸烟者也表现出生存率的提高（HR: 0.50, 95% CI: 0.31, 0.79）。RFS在吸烟行为上没有显著差异。结论：诊断后戒烟可改善OS，尤其是口腔癌患者，这突出了靶向戒烟干预在HNSCC护理中的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.