Exploring the bactericidal efficacy of a new potassium monopersulphate-based disinfectant.

IF 3.9 3区医学 Q1 INFECTIOUS DISEASES

Journal of Hospital Infection Pub Date : 2025-05-12 DOI:10.1016/j.jhin.2025.04.033

P P Barbosa, D M Leme, N G Motta, W L E Magalhães, J L Proenca-Modena, J-Y Maillard

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引用次数: 0

Abstract

Background: Staphylococcus aureus and Klebsiella pneumoniae are common pathogens responsible for hospital-acquired infections. Both species can survive on surfaces following desiccation and form dry surface biofilms (DSB), which complicates the disinfection process.

Aim: To evaluate the efficacy of an innovative potassium monopersulphate-based nanotechnology formulation (MPS) against both planktonic and sessile S. aureus and K. pneumoniae.

Methods: The bactericidal efficacy of MPS was tested in comparison with sodium hypochlorite (NaOCl) and didecyldimethylammonium chloride (DDAC), which served as controls. The assessment was performed against planktonic bacteria, hydrated biofilm, and dry surface biofilm (DSB) using standard suspension and carrier tests. Scanning electron microscopy (SEM) was employed to identify any gross structural damage.

Findings: MPS (2% w/v) achieved a ≥4 log₁₀ reduction in K. pneumoniae with a short contact time, regardless of the test protocol. S. aureus proved more resilient, but the introduction of wiping reduced the contact time needed to achieve a 4 log₁₀ reduction from 15 to 5 minutes. SEM analysis revealed gross structural damage in both species following MPS treatment. The other disinfectants tested were also bactericidal, achieving ≥4 log₁₀ reduction within 1-5 minutes, with the exception of DDAC against hydrated biofilms.

Conclusions: The potassium monopersulphate-based formulation was found to be an effective bactericide, including against dry surface biofilms (DSB). Its efficacy compares favourably with other biocides commonly used in healthcare settings, and its biodegradability makes it a promising candidate for further development. However, optimisation of the mechanical removal process will be essential to enhance MPS efficacy in practical applications.

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一种新型过硫酸钾基消毒剂的杀菌效果探讨。

背景：金黄色葡萄球菌和肺炎克雷伯菌是导致医院获得性感染的常见病原体。这两种细菌都能在干燥后的表面存活，并形成干燥的表面生物膜（DSB），这使消毒过程变得复杂。目的：评价一种创新的单过硫酸钾纳米制剂（MPS）对浮游和无根性金黄色葡萄球菌和肺炎克雷伯菌的治疗效果。方法：以次氯酸钠（NaOCl）、二烷基二甲基氯化铵（DDAC）为对照，比较多磺酸粘多糖的杀菌效果。采用标准悬浮液和载体试验对浮游细菌、水合生物膜和干燥表面生物膜（DSB）进行了评估。扫描电子显微镜（SEM）用于识别任何严重的结构损伤。结果：无论测试方案如何，MPS （2% w/v）在短接触时间内实现了肺炎克雷伯菌减少≥4 log10。事实证明，金黄色葡萄球菌更具弹性，但采用擦拭将接触时间从15分钟减少到5分钟，减少了4 log10。扫描电镜分析显示，在MPS处理后，两个物种的总体结构损伤。除DDAC对水合生物膜的作用外，其他测试消毒剂也具有杀菌作用，在1-5分钟内达到≥4 log10。结论：以过硫酸钾为基础的制剂是一种有效的杀菌剂，包括对干燥表面生物膜（DSB）的杀菌剂。其功效优于医疗环境中常用的其他杀菌剂，其生物降解性使其成为进一步开发的有希望的候选者。然而，机械去除过程的优化对于提高MPS在实际应用中的功效至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Hospital Infection 医学-传染病学

CiteScore

12.70

自引率

5.80%

发文量

271

审稿时长

19 days

期刊介绍： The Journal of Hospital Infection is the editorially independent scientific publication of the Healthcare Infection Society. The aim of the Journal is to publish high quality research and information relating to infection prevention and control that is relevant to an international audience. The Journal welcomes submissions that relate to all aspects of infection prevention and control in healthcare settings. This includes submissions that: provide new insight into the epidemiology, surveillance, or prevention and control of healthcare-associated infections and antimicrobial resistance in healthcare settings; provide new insight into cleaning, disinfection and decontamination; provide new insight into the design of healthcare premises; describe novel aspects of outbreaks of infection; throw light on techniques for effective antimicrobial stewardship; describe novel techniques (laboratory-based or point of care) for the detection of infection or antimicrobial resistance in the healthcare setting, particularly if these can be used to facilitate infection prevention and control; improve understanding of the motivations of safe healthcare behaviour, or describe techniques for achieving behavioural and cultural change; improve understanding of the use of IT systems in infection surveillance and prevention and control.