A Multi-Regional Epidemiological Evaluation on Post-vaccination Serological Testing in Prevention of Vertical Transmission of Hepatitis B Virus - 10 Counties, 5 Provinces, China, 2019-2024.

IF 4.3 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

中国疾病预防控制中心周报 Pub Date : 2025-05-09 DOI:10.46234/ccdcw2025.108

Lin Tang, Lun Li, Lifang Huang, Jing An, Yang Zhou, Yi Liu, Xiaoxue Liu, Qianqian Liu, Xiaoqi Wang, Siyu Liu, Hong Yang, Ning Wen, Zundong Yin, Fuzhen Wang

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Abstract

What is already known about this topic?: Post-vaccination serologic testing (PVST) of infants born to hepatitis B virus (HBV) infected mothers is important for evaluating effectiveness of strategies for preventing mother-to-child transmission (MTCT) of HBV.

What is added by this report?: PVST was conducted in 43.7% of 7,425 infants born to HBV-infected mothers and showed that 0.8% of infants had breakthrough infections, indicating a very low level of prevention failure; anti-HBs positivity was 97.0% showing vaccine-induced protection; and 2.2% of HBV-exposed infants needed revaccination. Prevention failure was 12.7-fold higher among infants born to HBeAg-positive mothers.

What are the implications for public health practice?: MTCT prevention strategy is highly effective. PVST evaluates MTCT prevention strategy and identifies infants needing revaccination; its use should be increased. Findings support WHO's HBV elimination strategy.

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疫苗接种后血清学检测预防乙型肝炎病毒垂直传播的多区域流行病学评价——中国5省10县2019-2024年

关于这个话题我们已经知道了什么？乙型肝炎病毒（HBV）感染母亲所生婴儿的疫苗接种后血清学检测（PVST）对于评估预防HBV母婴传播（MTCT）策略的有效性非常重要。这份报告增加了什么内容？在感染乙肝病毒的母亲所生的7425名婴儿中，有43.7%的婴儿进行了PVST，结果显示，0.8%的婴儿出现突破性感染，这表明预防失败的程度很低；抗hbs阳性率为97.0%，显示疫苗诱导的保护作用；2.2%的hbv暴露婴儿需要重新接种疫苗。hbeag阳性母亲所生婴儿的预防失败率高出12.7倍。这对公共卫生实践有什么影响？预防母婴传播战略非常有效。PVST评估母婴传播预防策略并确定需要重新接种疫苗的婴儿；它的使用应该增加。研究结果支持世卫组织的乙肝消除战略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

中国疾病预防控制中心周报

CiteScore

5.90

自引率

0.00%

发文量