The GENESTAR manual for biospecimen collection biobanking and omics data generation from commercial space missions.

IF 4.4 1区物理与天体物理 Q1 MULTIDISCIPLINARY SCIENCES

npj Microgravity Pub Date : 2025-05-14 DOI:10.1038/s41526-025-00472-1

Aparna Krishnavajhala, Marie-Claude Gingras, Emmanuel Urquieta, Hsu Chao, Dilrukshi Bandaranaike, Yi Chen, Sravya Bhamidipati, Viktoriya Korchina, S Michelle Griffin, Michal M Masternak, Hannah Moreno, Javid Mohammed, Mullai Murugan, Jennifer E Posey, Jimmy H Wu, Donna Muzny, Richard A Gibbs, Harsha Doddapaneni

{"title":"The GENESTAR manual for biospecimen collection biobanking and omics data generation from commercial space missions.","authors":"Aparna Krishnavajhala, Marie-Claude Gingras, Emmanuel Urquieta, Hsu Chao, Dilrukshi Bandaranaike, Yi Chen, Sravya Bhamidipati, Viktoriya Korchina, S Michelle Griffin, Michal M Masternak, Hannah Moreno, Javid Mohammed, Mullai Murugan, Jennifer E Posey, Jimmy H Wu, Donna Muzny, Richard A Gibbs, Harsha Doddapaneni","doi":"10.1038/s41526-025-00472-1","DOIUrl":null,"url":null,"abstract":"<p><p>The surge in commercial and civilian spaceflight enables the systematic and longitudinal, large-scale biospecimen collection to understand the prospective effects of space travel on human health. The Genomics and Space Medicine (Space Omics) project at BCM-HGSC involves a comprehensive biospecimen collection plan from commercial/private space flight participants. The manuscript addresses the critical gaps in the biospecimen collection process including details of the informed consent process, a provision for subjects to obtain custom CLIA-WGS reports, a data dictionary and a LIMS enabled biobank. The manuscript also discusses the biospecimens collection, processing methodologies and nucleic acid suitability for Omics data generation. Results from Axiom-2 mission where, 339 biospecimens were collected using 'Genomic Evaluation of Space Travel and Research (GENESTAR)' manual, at two different sites, showed that 98% of the blood samples and 91.6% of the non-blood samples passed the QC requirements for Omics assays, underscoring the reliability and effectiveness of the GENESTAR manual.</p>","PeriodicalId":54263,"journal":{"name":"npj Microgravity","volume":"11 1","pages":"16"},"PeriodicalIF":4.4000,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12078511/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"npj Microgravity","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1038/s41526-025-00472-1","RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

The surge in commercial and civilian spaceflight enables the systematic and longitudinal, large-scale biospecimen collection to understand the prospective effects of space travel on human health. The Genomics and Space Medicine (Space Omics) project at BCM-HGSC involves a comprehensive biospecimen collection plan from commercial/private space flight participants. The manuscript addresses the critical gaps in the biospecimen collection process including details of the informed consent process, a provision for subjects to obtain custom CLIA-WGS reports, a data dictionary and a LIMS enabled biobank. The manuscript also discusses the biospecimens collection, processing methodologies and nucleic acid suitability for Omics data generation. Results from Axiom-2 mission where, 339 biospecimens were collected using 'Genomic Evaluation of Space Travel and Research (GENESTAR)' manual, at two different sites, showed that 98% of the blood samples and 91.6% of the non-blood samples passed the QC requirements for Omics assays, underscoring the reliability and effectiveness of the GENESTAR manual.

查看原文本刊更多论文

生物标本收集、生物银行和商业太空任务组学数据生成的GENESTAR手册。

商业和民用航天飞行的激增使系统和纵向的大规模生物标本收集能够了解太空旅行对人类健康的预期影响。BCM-HGSC的基因组学和空间医学（空间组学）项目涉及商业/私人太空飞行参与者的全面生物标本收集计划。该手稿解决了生物标本收集过程中的关键空白，包括知情同意过程的细节，受试者获得自定义CLIA-WGS报告的规定，数据字典和LIMS支持的生物库。本文还讨论了生物标本的收集、处理方法和核酸对组学数据生成的适用性。Axiom-2任务在两个不同地点使用“太空旅行和研究基因组评估（GENESTAR）”手册收集了339个生物标本，结果显示98%的血液样本和91.6%的非血液样本通过了组学分析的QC要求，强调了GENESTAR手册的可靠性和有效性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

npj Microgravity Physics and Astronomy-Physics and Astronomy (miscellaneous)

CiteScore

7.30

自引率

7.80%

发文量

审稿时长

9 weeks

期刊介绍： A new open access, online-only, multidisciplinary research journal, npj Microgravity is dedicated to publishing the most important scientific advances in the life sciences, physical sciences, and engineering fields that are facilitated by spaceflight and analogue platforms.