Canonical and non-canonical roles of oligodendrocyte precursor cells in mental disorders.

Giulia Poggi, Giulia Treccani, Martina von der Bey, Arnaud Tanti, Michael J Schmeisser, Marianne Müller
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引用次数: 0

Abstract

Psychiatric research has shifted from a neuroncentric view to understanding mental disorders as disturbances of heterogeneous brain networks. Oligodendrocyte precursor cells (OPCs)- actively involved in the modulation of neuronal functions - are altered in psychiatric patients, but the extent and related consequences are unclear. This review explores canonical and non-canonical OPC-related pathways in schizophrenia, bipolar disorder, post-traumatic stress disorder, and depression in humans, highlighting potential mechanisms shared across diagnostic entities.

少突胶质前体细胞在精神障碍中的典型和非典型作用。
精神病学研究已经从以神经为中心的观点转变为将精神障碍理解为异质脑网络的干扰。少突胶质前体细胞(OPCs)-积极参与神经元功能的调节-在精神病患者中发生改变,但其程度和相关后果尚不清楚。本综述探讨了人类精神分裂症、双相情感障碍、创伤后应激障碍和抑郁症的规范和非规范opc相关通路,强调了诊断实体之间共享的潜在机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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