Giulia Poggi, Giulia Treccani, Martina von der Bey, Arnaud Tanti, Michael J Schmeisser, Marianne Müller
{"title":"Canonical and non-canonical roles of oligodendrocyte precursor cells in mental disorders.","authors":"Giulia Poggi, Giulia Treccani, Martina von der Bey, Arnaud Tanti, Michael J Schmeisser, Marianne Müller","doi":"10.1038/s44184-025-00133-x","DOIUrl":null,"url":null,"abstract":"<p><p>Psychiatric research has shifted from a neuroncentric view to understanding mental disorders as disturbances of heterogeneous brain networks. Oligodendrocyte precursor cells (OPCs)- actively involved in the modulation of neuronal functions - are altered in psychiatric patients, but the extent and related consequences are unclear. This review explores canonical and non-canonical OPC-related pathways in schizophrenia, bipolar disorder, post-traumatic stress disorder, and depression in humans, highlighting potential mechanisms shared across diagnostic entities.</p>","PeriodicalId":74321,"journal":{"name":"Npj mental health research","volume":"4 1","pages":"19"},"PeriodicalIF":0.0000,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081632/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Npj mental health research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1038/s44184-025-00133-x","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Psychiatric research has shifted from a neuroncentric view to understanding mental disorders as disturbances of heterogeneous brain networks. Oligodendrocyte precursor cells (OPCs)- actively involved in the modulation of neuronal functions - are altered in psychiatric patients, but the extent and related consequences are unclear. This review explores canonical and non-canonical OPC-related pathways in schizophrenia, bipolar disorder, post-traumatic stress disorder, and depression in humans, highlighting potential mechanisms shared across diagnostic entities.