Impact of Cribriform Pattern on Progression-Free Survival After Radical Prostatectomy in Gleason Score 8-10 Prostate Cancer.

IF 0.9 Q3 MEDICINE, GENERAL & INTERNAL

Eurasian Journal of Medicine Pub Date : 2025-04-21 DOI:10.5152/eurasianjmed.2025.25804

Tyler Walburn, Yetkin Tuaç, Çağdaş Aktan, Okan Argun, Luke W Chen, David D Yang, Shalini Moningi, Jonathan E Leeman, Peter F Orio, Paul L Nguyen, Anthony V D'Amico, Mutlay Sayan

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引用次数: 0

Abstract

Background: Although extensive research highlights the detrimental effect of cribriform pattern 4 (CP4) on survival in non-high-risk prostate cancer (PC), its prognostic significance in high-risk PC is not well understood. Methods: The individual patient data from the The Cancer Genome Atlas (TCGA) database following radical prostatectomy was retrospectively examined. A predefined statistical analysis was conducted to evaluate the potential association between CP4 and progression-free survival (PFS). Results: Of the 135 patients examined, CP4 was present in 66 (48.9%). Median follow-up was 45.93 months (interquartile range: 22.87, 80.10). Cribriform pattern 4 was associated with a significantly reduced PFS (subdistribution hazard ratio, 1.99; 95% CI, 1.01-3.92; P=.045) following adjustment for covariates. Conclusions: The presence of CP4 in high-risk Gleason 8-10 PC portends worse PFS. Further studies are warranted to fully understand its implications in risk stratification and post-operative management of PC.

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筛状模式对Gleason评分8-10分前列腺癌根治性前列腺切除术后无进展生存的影响。

背景：尽管大量研究强调了筛状模式4 （CP4）对非高危前列腺癌（PC）患者生存的不利影响，但其在高危前列腺癌（PC）中的预后意义尚不清楚。方法：回顾性分析根治性前列腺切除术后癌症基因组图谱（TCGA）数据库中的个体患者数据。进行了预先定义的统计分析，以评估CP4与无进展生存期（PFS）之间的潜在关联。结果：135例患者中，66例（48.9%）存在CP4。中位随访时间为45.93个月（四分位数间距：22.87,80.10）。筛网型4与PFS显著降低相关(亚分布风险比，1.99；95% ci, 1.01-3.92；P=.045)。结论：高危Gleason 8-10 PC中存在CP4预示着更差的PFS。进一步的研究需要充分了解其在前列腺癌风险分层和术后管理中的意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Eurasian Journal of Medicine Medicine-Medicine (all)

CiteScore

1.90

自引率

6.70%

发文量

审稿时长

16 weeks

期刊介绍： Eurasian Journal of Medicine (Eurasian J Med) is an international, scientific, open access periodical published by independent, unbiased, and triple-blinded peer-review principles. The journal is the official publication of Atatürk University School of Medicine and published triannually in February, June, and October. The publication language of the journal is English. The aim of the Eurasian Journal of Medicine is to publish original research papers of the highest scientific and clinical value in all medical fields. The Eurasian J Med also includes reviews, editorial short notes and letters to the editor that either as a comment related to recently published articles in our journal or as a case report. The target audience of the journal includes researchers, physicians and healthcare professionals who are interested or working in in all medical disciplines.