The global prevalence of co-occurrence of Sjögren syndrome and Hepatitis C virus infection: A systematic review and meta-analysis

IF 2.5 4区医学 Q3 VIROLOGY

Virus research Pub Date : 2025-05-13 DOI:10.1016/j.virusres.2025.199585

Nasir Arefinia , Hedyeh Askarpour , Zohreh-Al-Sadat Ghoreshi , Habibeh Mashayekhi-Sardoo , Mohammad Ali-Hassanzadeh

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引用次数: 0

Abstract

Sjögren syndrome (SS) is one of the lesser-known autoimmune diseases, with its mechanisms and pathogenesis not yet fully understood. However, recent studies indicate that infectious diseases, such as Hepatitis C virus (HCV) infection, may serve as risk factors for the development of SS. Accordingly, this study aimed to estimate the global co-occurrence rate of chronic HCV infection and SS. In this systematic review and meta-analysis, a comprehensive search for relevant studies was conducted in PubMed, Scopus, ISI Web of Science, and Google Scholar databases up to June 2024. Data from eligible studies were meticulously extracted and statistically analyzed using Comprehensive Meta-Analysis Software. The pooled prevalence of co-occurrence of HCV and SS was calculated using incidence rates with 95 % confidence intervals (CIs), and the association of chronic HCV infection with the development of SS was assessed via odds ratios (ORs) with 95 % CIs. Analysis of the articles retrieved from the databases showed 24 studies were considered eligible. The pooled estimate for the co-occurrence of HCV and SS was approximately 16.6 % (95 % CI: 8.8–28.9). Moreover, the results indicated that chronic HCV infection significantly increased the risk of developing SS (OR: 2.76; 95 % CI: 1.35–5.63). This study's findings revealed that HCV infection may play a role in the pathogenesis of and susceptibility to SS. Therefore, chronic HCV infection may trigger the onset of SS. However, further studies are required to confirm these results.

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Sjögren综合征和丙型肝炎病毒感染共发的全球患病率：一项系统回顾和荟萃分析

Sjögren综合征（SS）是一种鲜为人知的自身免疫性疾病，其机制和发病机制尚不完全清楚。然而，最近的研究表明，感染性疾病，如丙型肝炎病毒（HCV）感染可能是SS发生的危险因素。因此，本研究旨在估计慢性HCV感染和SS的全球共发病率。在本系统综述和荟萃分析中，我们在PubMed、Scopus、ISI Web of Science和谷歌Scholar数据库中全面检索了截至2024年6月的相关研究。从符合条件的研究中提取数据，并使用综合meta分析软件进行统计分析。使用95%可信区间（ci）的发生率计算HCV和SS共发生的总患病率，并通过95% ci的优势比（ORs）评估慢性HCV感染与SS发生的相关性。从数据库中检索到的文章分析显示，24项研究被认为是合格的。HCV和SS共发生的合并估计约为16.6% （95% CI: 8.8-28.9）。此外，结果显示慢性HCV感染显著增加SS发生的风险(OR: 2.76；95% ci: 1.35-5.63)。本研究结果提示，HCV感染可能参与了SS的发病机制和易感性，因此慢性HCV感染可能触发SS的发病，但这些结果还需要进一步的研究来证实。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Virus research 医学-病毒学

CiteScore

9.50

自引率

2.00%

发文量

239

审稿时长

43 days

期刊介绍： Virus Research provides a means of fast publication for original papers on fundamental research in virology. Contributions on new developments concerning virus structure, replication, pathogenesis and evolution are encouraged. These include reports describing virus morphology, the function and antigenic analysis of virus structural components, virus genome structure and expression, analysis on virus replication processes, virus evolution in connection with antiviral interventions, effects of viruses on their host cells, particularly on the immune system, and the pathogenesis of virus infections, including oncogene activation and transduction.