From Tooth to Vision: A Decade of Breakthroughs in Osteo-Odonto-Keratoprosthesis (OOKP) and Modified OOKP-Global Insights into Surgical Techniques, Outcomes, and Pioneering Research.

IF 1.9 4区医学 Q2 OPHTHALMOLOGY

Seminars in Ophthalmology Pub Date : 2025-05-15 DOI:10.1080/08820538.2025.2503910

Alexandra France, Harsha De Silva, Darryl Tong, Li Mei, Guangzhao Guan

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引用次数: 0

Abstract

Purpose: Osteo-odonto-keratoprosthesis (OOKP), or "tooth-in-eye" surgery, is a pivotal technique developed for the treatment of severe corneal blindness in patients unsuitable for traditional corneal transplantation. This review aims to highlight the evolution, current advancements, and global adoption of OOKP, particularly for individuals with end-stage ocular surface disease.

Methods: A comprehensive and systematic literature search was conducted across Embase, PubMed, Scopus, and Web of Science for articles published between 2014 and 2024, using the keyword search terms: "osteo-odontokeratoprosthesis" OR osteoodontokeratoprosthesis OR "osteo-odonto-keratoprosthesis" OR OOKP OR MOOKP.

Results: OOKP remains uniquely effective for cases of severe ocular surface damage, including Stevens-Johnson syndrome and chemical or thermal burns. Long-term data demonstrate consistent visual rehabilitation and prosthesis retention across diverse populations in Europe, Asia, and South America. Advancements have improved tissue integration and reduced complications like graft resorption and secondary glaucoma. Innovations in surgical precision have further minimized tissue trauma and improved postoperative stability.

Conclusions: Despite its complexity, OOKP continues to evolve through surgical and material innovations, reflecting a sustained global commitment to improving visual outcomes in patients with otherwise untreatable corneal blindness. The continuous refinement of this technique holds promise for expanding its accessibility and success worldwide, paving the way for future advancements in keratoprosthesis surgery.

查看原文本刊更多论文

从牙齿到视力：骨-牙-角膜假体（OOKP）和改良OOKP的十年突破-外科技术，结果和开创性研究的全球见解。

目的：骨-齿-角膜假体（OOKP），或“眼内牙”手术，是治疗不适合传统角膜移植的严重角膜失明患者的关键技术。本综述旨在强调OOKP的演变、当前进展和全球采用，特别是对于终末期眼表疾病患者。方法：通过Embase、PubMed、Scopus、Web of Science对2014 - 2024年间发表的文章进行全面、系统的文献检索，检索关键词为“osteo-odontokeratoprosthesis”或“osteo-odontokeratoprosthesis”或“osteo-odontokeratoprosthesis”或“OOKP”或“MOOKP”。结果：对于严重眼表损伤，包括Stevens-Johnson综合征和化学或热烧伤，OOKP仍然是唯一有效的病例。长期数据表明，在欧洲、亚洲和南美的不同人群中，视力康复和假体保留是一致的。技术进步改善了组织整合，减少了移植物吸收和继发性青光眼等并发症。手术精度的创新进一步减少了组织创伤，提高了术后稳定性。结论：尽管它很复杂，但OOKP通过手术和材料的创新不断发展，反映了全球对改善无法治疗的角膜失明患者视力结果的持续承诺。这项技术的不断完善有望扩大其在世界范围内的可及性和成功，为未来角膜移植手术的发展铺平道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in Ophthalmology OPHTHALMOLOGY-

CiteScore

3.20

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Seminars in Ophthalmology offers current, clinically oriented reviews on the diagnosis and treatment of ophthalmic disorders. Each issue focuses on a single topic, with a primary emphasis on appropriate surgical techniques.