Impact of COVID-19 Vaccination and Infection on Anti-Triple-Knockout (TKO) Pig Antibody Production: A Study in Patients With End-Stage Liver Disease and Liver Transplant Recipients.

IF 3.3 4区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Xenotransplantation Pub Date : 2025-05-01 DOI:10.1111/xen.70050

Liaoran Wang, Li Zhuang, Tao Li, Hidetaka Hara, David K C Cooper, Jianhang Leng, Dengke Pan, Shusen Zheng, Yi Wang, Xiao Xu, Qiang Wei

{"title":"Impact of COVID-19 Vaccination and Infection on Anti-Triple-Knockout (TKO) Pig Antibody Production: A Study in Patients With End-Stage Liver Disease and Liver Transplant Recipients.","authors":"Liaoran Wang, Li Zhuang, Tao Li, Hidetaka Hara, David K C Cooper, Jianhang Leng, Dengke Pan, Shusen Zheng, Yi Wang, Xiao Xu, Qiang Wei","doi":"10.1111/xen.70050","DOIUrl":null,"url":null,"abstract":"<p><p>This study investigates the impact of COVID-19 vaccination, with a focus on inactivated vaccines, on the production of anti-triple-knockout (TKO) pig antibodies, crucial for xenotransplantation. Although it is known that vaccination influences anti-pig antibody production, the specific effects of COVID-19 vaccines, particularly inactivated forms, remain underexplored. We analyzed serum samples from healthy individuals, patients with end-stage liver disease (ESLD), and liver transplant (LT) recipients to assess antibody binding to TKO pig cells. Our findings reveal a significant difference in anti-TKO pig antibody levels among healthy controls, ESLD patients, and LT recipients. A positive correlation was observed between SARS-CoV-2 IgG and anti-TKO pig IgG levels in ESLD patients. Additionally, LT recipients with active COVID-19 infection showed significantly higher levels of anti-TKO pig IgG antibodies. These results suggest that both inactivated COVID-19 vaccination and infection may potentially increase anti-TKO pig antibody production. This underscores the importance of closely monitoring anti-pig antibody levels in potential xenotransplant recipients following COVID-19 vaccination or infection, highlighting the need for further research to optimize xenotransplantation protocols in the post-pandemic era.</p>","PeriodicalId":23866,"journal":{"name":"Xenotransplantation","volume":"32 3","pages":"e70050"},"PeriodicalIF":3.3000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Xenotransplantation","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/xen.70050","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}

引用次数: 0

Abstract

This study investigates the impact of COVID-19 vaccination, with a focus on inactivated vaccines, on the production of anti-triple-knockout (TKO) pig antibodies, crucial for xenotransplantation. Although it is known that vaccination influences anti-pig antibody production, the specific effects of COVID-19 vaccines, particularly inactivated forms, remain underexplored. We analyzed serum samples from healthy individuals, patients with end-stage liver disease (ESLD), and liver transplant (LT) recipients to assess antibody binding to TKO pig cells. Our findings reveal a significant difference in anti-TKO pig antibody levels among healthy controls, ESLD patients, and LT recipients. A positive correlation was observed between SARS-CoV-2 IgG and anti-TKO pig IgG levels in ESLD patients. Additionally, LT recipients with active COVID-19 infection showed significantly higher levels of anti-TKO pig IgG antibodies. These results suggest that both inactivated COVID-19 vaccination and infection may potentially increase anti-TKO pig antibody production. This underscores the importance of closely monitoring anti-pig antibody levels in potential xenotransplant recipients following COVID-19 vaccination or infection, highlighting the need for further research to optimize xenotransplantation protocols in the post-pandemic era.

查看原文本刊更多论文

COVID-19疫苗接种和感染对抗三敲除（TKO）猪抗体产生的影响：终末期肝病患者和肝移植受者的研究

本研究调查了COVID-19疫苗接种（重点是灭活疫苗）对抗三敲除（TKO）猪抗体产生的影响，这对异种移植至关重要。虽然已知疫苗接种会影响抗猪抗体的产生，但COVID-19疫苗，特别是灭活疫苗的具体效果仍未得到充分探索。我们分析了健康人、终末期肝病（ESLD）患者和肝移植（LT）受者的血清样本，以评估抗体与TKO猪细胞的结合。我们的研究结果显示，在健康对照组、ESLD患者和LT受体之间，抗tko猪抗体水平存在显著差异。ESLD患者SARS-CoV-2 IgG与抗tko猪IgG水平呈正相关。此外，活动性COVID-19感染的LT受体显示出明显更高的抗tko猪IgG抗体水平。这些结果表明，灭活的COVID-19疫苗接种和感染都可能增加抗tko猪抗体的产生。这强调了在COVID-19疫苗接种或感染后密切监测潜在异种移植受者抗猪抗体水平的重要性，强调了需要进一步研究以优化大流行后时代的异种移植方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Xenotransplantation 医学-医学：研究与实验

CiteScore

6.80

自引率

15.40%

发文量

审稿时长

>12 weeks

期刊介绍： Xenotransplantation provides its readership with rapid communication of new findings in the field of organ and tissue transplantation across species barriers.The journal is not only of interest to those whose primary area is xenotransplantation, but also to veterinarians, microbiologists and geneticists. It also investigates and reports on the controversial theological, ethical, legal and psychological implications of xenotransplantation.