Evaluating the initial and end-of-day wettability of contemporary daily disposable contact lenses using various in vitro methods.

IF 1.6 4区医学 Q3 OPHTHALMOLOGY

Optometry and Vision Science Pub Date : 2025-05-16 DOI:10.1097/OPX.0000000000002260

Chau-Minh Phan, Brandon Ho, Alex Hui, Hendrik Walther, Ying Zheng, Lakshman Subbaraman, Xinfeng Charlie Shi, James Wu, Lyndon William Jones

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引用次数: 0

Abstract

Significance: Contact lens wettability is potentially correlated with friction, which is linked to lens comfort. However, measuring wettability can be highly variable. This study assessed wettability using three techniques for a more accurate profile.

Purpose: To evaluate the wettability of contemporary daily disposable contact lenses after 16 hours on an in vitro model using the sessile drop, captive bubble, and a novel in vitro noninvasive keratograph breakup time (NIKBUT) method.

Methods: The wettability of six contemporary silicone hydrogel contact lens materials (verofilcon A, delefilcon A, senofilcon A, kalifilcon A, stenfilcon A, and somofilcon A) and two conventional hydrogel materials (nesofilcon A and etafilcon A) were evaluated using an in vitro blink model at t = 0 and 16 hours. The blink rates of the eye model were 20 blinks per minute. Sessile drop and captive bubble angles were analyzed using the Optical Contact Analyzer. NIKBUT was assessed on a blink model in combination with the OCULUS Keratograph 5M.

Results: There were no significant differences in wettability for any lens types between 0 and 16 hours when assessed using the captive bubble or NIKBUT methods (p>0.05). For the sessile drop method, verofilcon A had the lowest contact angle values (36.5 ± 2.9°), and all lenses except for etafilcon A had similar wettability after 16 hours. All the lenses had similar wettability when assessed using the captive bubble method, suggesting that they had similar wettability under optimal wetting conditions. For NIKBUT, delefilcon A had the longest NIKBUT values (9.0 ± 1.0 s) after 16 hours.

Conclusions: The sessile drop technique produced the most measurable differences in wettability between different lens types, whereas the captive bubble technique was not able to provide any measurable differences between lenses. NIKBUT measurements may provide a better measure of on-eye wettability, but variability in the results using the current eye model still needs to be addressed in future studies for improved repeatability. Although the contact lenses showed different contact angles and NIKBUT results, their in vitro wettability did not significantly change over the 16 hours of simulated wear in terms of the captive bubble or NIKBUT values.

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使用各种体外方法评估当代日用一次性隐形眼镜的初始和结束润湿性。

意义：隐形眼镜润湿性可能与摩擦有关，而摩擦与镜片舒适度有关。然而，测量润湿性可能是高度可变的。该研究使用三种技术来评估润湿性，以获得更准确的剖面。目的：采用无基滴法、俘虏泡法和一种新型的体外无创角膜镜破裂时间（NIKBUT）法，在体外模型上评价当代一次性日用隐形眼镜在16小时后的润湿性。方法：采用体外blink模型，分别在t = 0和16 h对六种现代硅酮水凝胶隐形眼镜材料（verofilcon A、delefilcon A、senofilcon A、kalifilcon A、stenfilcon A和somofilcon A）和两种传统水凝胶材料（nesofilcon A和etafilcon A）的润湿性进行评价。眼模型的眨眼频率为每分钟20次。用光学接触分析仪分析了固滴角和俘获泡角。结合OCULUS角膜摄影仪5M对NIKBUT进行眨眼模型评估。结果：当使用捕获气泡或NIKBUT方法评估时，任何类型的晶状体在0和16小时之间的润湿性没有显着差异（p>0.05）。对于固滴法，verafilcon A的接触角值最低（36.5±2.9°），除etafilcon A外，所有镜片在16小时后的润湿性相似。当使用俘获泡法评估时，所有的镜片都具有相似的润湿性，这表明它们在最佳润湿条件下具有相似的润湿性。对于NIKBUT， delefilcon A在16小时后NIKBUT值最长（9.0±1.0 s）。结论：无柄滴技术在不同类型的晶状体之间产生了最可测量的润湿性差异，而俘获泡技术不能在晶状体之间提供任何可测量的差异。NIKBUT测量可以更好地测量眼上润湿性，但使用当前眼睛模型的结果的可变性仍需要在未来的研究中解决，以提高可重复性。虽然隐形眼镜显示了不同的接触角度和NIKBUT结果，但在模拟佩戴的16小时内，它们的体外润湿性在圈闭泡或NIKBUT值方面没有显着变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Optometry and Vision Science 医学-眼科学

CiteScore

2.80

自引率

7.10%

发文量

210

审稿时长

3-6 weeks

期刊介绍： Optometry and Vision Science is the monthly peer-reviewed scientific publication of the American Academy of Optometry, publishing original research since 1924. Optometry and Vision Science is an internationally recognized source for education and information on current discoveries in optometry, physiological optics, vision science, and related fields. The journal considers original contributions that advance clinical practice, vision science, and public health. Authors should remember that the journal reaches readers worldwide and their submissions should be relevant and of interest to a broad audience. Topical priorities include, but are not limited to: clinical and laboratory research, evidence-based reviews, contact lenses, ocular growth and refractive error development, eye movements, visual function and perception, biology of the eye and ocular disease, epidemiology and public health, biomedical optics and instrumentation, novel and important clinical observations and treatments, and optometric education.