Jian-Zhe Li, Juan Pan, Yu Bi, Zhi-Chao Hao, Wei Guan, Hai-Xue Kuang, Qing-Shan Chen, Li-Li Zhang, Xin-Yue Wu, Da-Lin Li, Bing-You Yang, Yan Liu
{"title":"The undescribed alkaloids from <i>Jacobaea cannabifolia</i> (less.) E. Wiebe and their anti-inflammatory activities.","authors":"Jian-Zhe Li, Juan Pan, Yu Bi, Zhi-Chao Hao, Wei Guan, Hai-Xue Kuang, Qing-Shan Chen, Li-Li Zhang, Xin-Yue Wu, Da-Lin Li, Bing-You Yang, Yan Liu","doi":"10.1080/14786419.2025.2502145","DOIUrl":null,"url":null,"abstract":"<p><p>From the whole herb of <i>Jacobaea cannabifolia</i> (Less.) E. Wiebe, one new alkaloid named cannabliold E (<b>1</b>), one new natural alkaloid derivative named methyl 4-(2-oxo-1-pyrrolidinyl) benzene acetate (<b>2</b>) along with seven known alkaloids (<b>3-9</b>) were successfully isolated. The structures of the newly identified compounds were elucidated using NMR spectroscopy and HR-ESI-MS. The absolute configurations of compound <b>1</b> were assigned through electronic circular dichroism (ECD) analysis. Identification of the known compounds was achieved by comparing their 1D NMR data with literature references. All isolated compounds were assessed for anti-inflammatory activity against LPS-induced RAW 264.7 cells; results indicated that compounds <b>6</b> and <b>8</b> exhibited significant anti-inflammatory effects with IC<sub>50</sub> values below 1.59 ± 0.18 μM.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.9000,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/14786419.2025.2502145","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
From the whole herb of Jacobaea cannabifolia (Less.) E. Wiebe, one new alkaloid named cannabliold E (1), one new natural alkaloid derivative named methyl 4-(2-oxo-1-pyrrolidinyl) benzene acetate (2) along with seven known alkaloids (3-9) were successfully isolated. The structures of the newly identified compounds were elucidated using NMR spectroscopy and HR-ESI-MS. The absolute configurations of compound 1 were assigned through electronic circular dichroism (ECD) analysis. Identification of the known compounds was achieved by comparing their 1D NMR data with literature references. All isolated compounds were assessed for anti-inflammatory activity against LPS-induced RAW 264.7 cells; results indicated that compounds 6 and 8 exhibited significant anti-inflammatory effects with IC50 values below 1.59 ± 0.18 μM.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
