Targeting cholesterol-driven pyroptosis: a promising strategy for the prevention and treatment of atherosclerosis.

IF 2.6 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Biology Reports Pub Date : 2025-05-15 DOI:10.1007/s11033-025-10554-8

Yuehong Tang, Wenjuan Tong, Yujiao Peng, Shaowei Sun

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Abstract

Funding Pyroptosis is a type of programmed cell death (PCD) pathway distinguished by inflammation. It is activated by specific inflammasomes. Once activated, it causes the physical breakdown of the cell, along with the discharge of pro-inflammatory cytokines, such as interleukin-1β (IL-1β) and interleukin-18 (IL-18). Abundant evidence has demonstrated the existence of pyroptotic cell death within atherosclerotic plaques, which has significance for the development of atherosclerosis (AS). As a result, pyroptosis has become a new and important topic in cardiovascular disease (CVD) research. Cholesterol, it is recognized to have a connection with inflammation, exerts a crucial function in the development process of AS, and has been linked to the initiation of pyroptosis. This review aims to briefly summarize the fundamental aspects of pyroptosis and the influence of cholesterol-related inflammation in AS. Additionally, this review will explore potential therapeutic approaches based on pyroptosis that could be utilized for the prevention and treatment of AS.

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靶向胆固醇驱动的焦亡：预防和治疗动脉粥样硬化的一个有前途的策略。

基金性焦亡是一种以炎症为特征的程序性细胞死亡（PCD）途径。它被特定的炎性小体激活。一旦被激活，它会导致细胞的物理分解，同时释放促炎细胞因子，如白细胞介素-1β (IL-1β)和白细胞介素-18 （IL-18）。大量证据表明，动脉粥样硬化斑块内存在热噬细胞死亡，这对动脉粥样硬化（AS）的发生发展具有重要意义。因此，焦亡已成为心血管疾病（CVD）研究的一个新的重要课题。胆固醇被认为与炎症有关，在AS的发展过程中发挥着至关重要的作用，并与焦亡的发生有关。本文就AS热亡的基本情况及胆固醇相关炎症的影响作一综述。此外，本文将探讨基于焦亡的潜在治疗方法，可用于预防和治疗AS。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Biology Reports 生物-生化与分子生物学

CiteScore

5.00

自引率

0.00%

发文量

1048

审稿时长

5.6 months

期刊介绍： Molecular Biology Reports publishes original research papers and review articles that demonstrate novel molecular and cellular findings in both eukaryotes (animals, plants, algae, funghi) and prokaryotes (bacteria and archaea).The journal publishes results of both fundamental and translational research as well as new techniques that advance experimental progress in the field and presents original research papers, short communications and (mini-) reviews.