Frailty Is an Independent Marker of Post-Operative Mortality Following Colorectal Cancer Resection Surgery in Older Adults.

IF 2 3区医学 Q3 ONCOLOGY

Journal of Surgical Oncology Pub Date : 2025-05-15 DOI:10.1002/jso.28137

Maria Normann, Niklas Ekerstad, Eva Angenete, Mattias Prytz

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引用次数: 0

Abstract

Background and objectives: Frailty is a prognostic factor of post-operative death and complications following colorectal cancer surgery. Frailty assessment is not routinely performed, hence, the prevalence is unknown. The aim of this study was to establish the presence of frailty in patients aged ≥ 70 years, and to analyse differences in post-operative outcome comparing frail and non-frail elderly patients.

Method: Data of patients aged ≥ 70 years who underwent colorectal cancer surgery during 2016-2020 were retrospectively obtained from the Swedish Colorectal Cancer Registry. A cohort of 500 patients was assessed for frailty using the Clinical Frailty Scale (CFS-9). Post-operative mortality rates, complications, readmissions, and length of stay (LOS) were compared between frail and non-frail patients.

Results: The prevalence of frailty (CFS-9 score ≥ 4) was 56%. The 90-day mortality rate was higher in frail patients (OR 4.97 [95% CI 1.06-23.28], p 0.042), as well as 1-year mortality (OR 4.39 [95% CI 1.86-10.34], p 0.0007). Frail patients had longer post-operative LOS (7.63 vs. 11.0 days, p < 0.001), were more often treated in ICU and more often discharged to a nursing home.

Conclusion: Frailty is a common condition in patients ≥ 70 years and a significant risk factor of post-operative mortality and morbidity.

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虚弱是老年人结直肠癌切除术后死亡率的独立标志。

背景和目的：虚弱是结直肠癌术后死亡和并发症的预后因素。虚弱评估没有常规执行，因此，患病率是未知的。本研究的目的是确定年龄≥70岁的患者是否存在虚弱，并分析比较虚弱和非虚弱的老年患者术后结局的差异。方法：从瑞典结直肠癌登记处回顾性获取2016-2020年期间年龄≥70岁的结直肠癌手术患者的数据。采用临床虚弱量表（CFS-9）评估500例患者的虚弱程度。比较体弱和非体弱患者的术后死亡率、并发症、再入院率和住院时间（LOS）。结果：虚弱的患病率（CFS-9评分≥4）为56%。体弱患者的90天死亡率（OR 4.97 [95% CI 1.06-23.28], p 0.042）和1年死亡率（OR 4.39 [95% CI 1.86-10.34], p 0.0007）较高。虚弱患者术后LOS较长（7.63 vs 11.0天），p结论：虚弱是≥70岁患者的常见状况，是术后死亡率和发病率的重要危险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Surgical Oncology 医学-外科

CiteScore

4.70

自引率

4.00%

发文量

367

审稿时长

2 months

期刊介绍： The Journal of Surgical Oncology offers peer-reviewed, original papers in the field of surgical oncology and broadly related surgical sciences, including reports on experimental and laboratory studies. As an international journal, the editors encourage participation from leading surgeons around the world. The JSO is the representative journal for the World Federation of Surgical Oncology Societies. Publishing 16 issues in 2 volumes each year, the journal accepts Research Articles, in-depth Reviews of timely interest, Letters to the Editor, and invited Editorials. Guest Editors from the JSO Editorial Board oversee multiple special Seminars issues each year. These Seminars include multifaceted Reviews on a particular topic or current issue in surgical oncology, which are invited from experts in the field.