Supplementation Containing Bromelain on the Side Effects of Oncological Treatment: Systematic Review.

IF 1.7 3区农林科学 Q4 CHEMISTRY, MEDICINAL

Journal of medicinal food Pub Date : 2025-05-15 DOI:10.1089/jmf.2023.0027

Irislene Costa Pereira, Raquel Barros Passos, Camila de Meneses Caetano Viana, Isabele Frazão Mascarenhas, Glauto Tuquarre de Melo Nascimento, Felipe Cavalcanti Carneiro da Silva, João Marcelo de Castro E Sousa, Francisco Leonardo Torres-Leal

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引用次数: 0

Abstract

Systemic therapies for the treatment of cancer collaborate to reduce cancer progression and have been used for decades. However, despite the clinical benefits, its long-term use is associated with toxicity, promoting important side effects that can compromise the quality of life. Enzyme supplementation has been pointed out as a therapeutic potential in several diseases. Bromelain is an enzyme complex that regulates pathways associated with inflammation. This review aims to evaluate the use of bromelain-containing supplements to improve the side effects of cancer treatment. This systematic review was developed in PubMed, Web of Science, and Cochrane Library, using the terms: Cancer AND Bromelain. 239 studies were retrieved, and only three met our objective. In general, it was possible to observe that supplementation was able to reduce side effects of adjuvant hormone therapy and chemotherapy, such as mucosal dryness, arthralgia, and peripheral neuropathy induced by chemotherapy.

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补充菠萝蛋白酶对肿瘤治疗副作用的影响：系统综述。

用于治疗癌症的全身疗法合作，以减少癌症的进展，并已使用了几十年。然而，尽管有临床益处，其长期使用与毒性有关，促进了可能损害生活质量的重要副作用。酶补充已被指出在几种疾病的治疗潜力。菠萝蛋白酶是一种调节炎症相关途径的酶复合物。本综述旨在评价含菠萝蛋白酶补充剂的使用，以改善癌症治疗的副作用。本系统综述是在PubMed、Web of Science和Cochrane Library中开发的，使用的术语是：癌症和菠萝蛋白酶。239项研究被检索到，只有3项符合我们的目标。总的来说，有可能观察到补充能够减少辅助激素治疗和化疗的副作用，如化疗引起的粘膜干燥、关节痛和周围神经病变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of medicinal food 医学-食品科技

CiteScore

4.50

自引率

0.00%

发文量

154

审稿时长

4.5 months

期刊介绍： Journal of Medicinal Food is the only peer-reviewed journal focusing exclusively on the medicinal value and biomedical effects of food materials. International in scope, the Journal advances the knowledge of the development of new food products and dietary supplements targeted at promoting health and the prevention and treatment of disease.