Emergence of extensively drug-resistant Salmonella Kentucky ST198 in Southwest China

IF 3.2 3区医学 Q2 INFECTIOUS DISEASES

Journal of global antimicrobial resistance Pub Date : 2025-06-01 DOI:10.1016/j.jgar.2025.05.009

Ximei Kong , Jian Wang , Gaopeng Lei , Yang Yang , Weifeng Huang , Yun Leng , Yanfang Miao , Ming Li , Qiwu Yuan , Yuanyuan Zhao , Xin Xu , Haojiang Zuo , Lvbo Tian

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引用次数: 0

Abstract

Objectives

The study aimed to investigate the prevalence, antimicrobial resistance profiles, and virulence characteristics of Salmonella isolates from clinical cases in Sichuan, China, collected from 2019 to 2021.

Methods

A total of 153 Salmonella isolates from 19 regions in Sichuan Province were analysed. Sequence types (STs) were identified using multi-locus sequence typing. Antimicrobial susceptibility testing was conducted to assess resistance profiles, while whole-genome sequencing was used to detect antimicrobial resistance genes (ARGs) and virulence genes.

Results

Among the 153 Salmonella isolates, 49 STs were identified. ST11 (S. Enteritidis) was the most prevalent, while S. Kentucky comprised 3.27% (5/153) of isolates, significantly higher than the national average (0.33%, P < 0.05). All S. Kentucky ST198 isolates were extensively drug-resistant, exhibiting resistance to at least seven antimicrobial classes, including fluoroquinolones and extended-spectrum cephalosporins. S. Kentucky ST198 harboured significantly more ARGs (P < 0.001) and virulence genes (P < 0.001) than other strains. ARGs such as CTX-M-55, TEM-216, TEM-90, and TEM-150 were significantly more prevalent (P < 0.05), conferring resistance to extended-spectrum cephalosporins and β-lactams. Additionally, the absence of sifA (16.7% vs. 91.8%, P < 0.001) and shdA (0.0% vs. 68.7%, P = 0.001), suggesting that these genes may influence the reduced risk of human infection by ST198.

Conclusions

These findings highlight the emergence of extensively drug-resistant Salmonella Kentucky ST198 in Southwest China and underscore the urgent need for ongoing surveillance in this region due to its significant public health impact.

查看原文本刊更多论文

广泛耐药的肯塔基沙门氏菌ST198在中国西南地区的出现。

目的：调查2019 - 2021年中国四川省临床病例中分离的沙门氏菌的流行情况、耐药性特征和毒力特征。方法：对四川省19个地区分离的153株沙门氏菌进行分析。序列类型（STs）采用多位点序列分型（MLST）鉴定。采用药敏试验评估耐药谱，全基因组测序检测耐药基因（ARGs）和毒力基因。结果：153株沙门氏菌分离物中鉴定出st 49株。ST11（肠炎沙门氏菌）最为普遍，而肯塔基沙门氏菌占3.27%(5/153)，显著高于全国平均水平（0.33%）。结论：这些发现突出了广泛耐药肯塔基沙门氏菌ST198在中国西南地区的出现，并强调了由于其对公共卫生的重大影响，迫切需要在该地区进行持续监测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of global antimicrobial resistance INFECTIOUS DISEASES-PHARMACOLOGY & PHARMACY

CiteScore

8.70

自引率

2.20%

发文量

285

审稿时长

34 weeks

期刊介绍： The Journal of Global Antimicrobial Resistance (JGAR) is a quarterly online journal run by an international Editorial Board that focuses on the global spread of antibiotic-resistant microbes. JGAR is a dedicated journal for all professionals working in research, health care, the environment and animal infection control, aiming to track the resistance threat worldwide and provides a single voice devoted to antimicrobial resistance (AMR). Featuring peer-reviewed and up to date research articles, reviews, short notes and hot topics JGAR covers the key topics related to antibacterial, antiviral, antifungal and antiparasitic resistance.