"What's in a name?" Clarifying the identity of RORγt+ antigen-presenting cells.

IF 12.6 1区医学 Q1 IMMUNOLOGY

Journal of Experimental Medicine Pub Date : 2025-08-04 Epub Date: 2025-05-15 DOI:10.1084/jem.20250760

Feiya Ou, Kenneth M Murphy

引用次数: 0

Abstract

Recent publications have demonstrated that antigen-presenting cells (APCs) targeted by Rorc-cre (also known as RORγt-cre) are required for the induction of peripheral regulatory T (pTreg) cells in response to commensal and dietary antigens. In this issue of JEM, Sun et al. (https://doi.org/10.1084/jem.20250573) provide key insights into the identity of these cells, revealing that Rorc-cre-traced APCs include group 3 innate lymphoid cells (ILC3s), dendritic cells (DCs), and extrathymic AIRE-expressing cells (eTACs). Their work highlights eTACs as critical for inducing RORγt+ pTregs specific to food antigens, while implicating DCs in the generation of RORγt- pTregs.

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“名字有什么用？”澄清RORγt+抗原呈递细胞的身份。

最近的研究表明，Rorc-cre（也称为rorγ - T -cre）靶向的抗原呈递细胞（APCs）是诱导外周调节性T细胞（pTreg）对共生抗原和膳食抗原做出反应所必需的。在本期《JEM》中，Sun等人（https://doi.org/10.1084/jem.20250573）提供了这些细胞身份的关键见解，揭示了rorc - crec追踪的apc包括第3组先天淋巴样细胞（ILC3s）、树突状细胞（dc）和胸腺外aire表达细胞（eTACs）。他们的工作强调了eTACs对于诱导食物抗原特异性的RORγt+ ptreg至关重要，同时暗示dc在RORγt- ptreg的产生中起作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Experimental Medicine 医学-免疫学

CiteScore

26.60

自引率

1.30%

发文量

189

审稿时长

3-8 weeks

期刊介绍： Since its establishment in 1896, the Journal of Experimental Medicine (JEM) has steadfastly pursued the publication of enduring and exceptional studies in medical biology. In an era where numerous publishing groups are introducing specialized journals, we recognize the importance of offering a distinguished platform for studies that seamlessly integrate various disciplines within the pathogenesis field. Our unique editorial system, driven by a commitment to exceptional author service, involves two collaborative groups of editors: professional editors with robust scientific backgrounds and full-time practicing scientists. Each paper undergoes evaluation by at least one editor from both groups before external review. Weekly editorial meetings facilitate comprehensive discussions on papers, incorporating external referee comments, and ensure swift decisions without unnecessary demands for extensive revisions. Encompassing human studies and diverse in vivo experimental models of human disease, our focus within medical biology spans genetics, inflammation, immunity, infectious disease, cancer, vascular biology, metabolic disorders, neuroscience, and stem cell biology. We eagerly welcome reports ranging from atomic-level analyses to clinical interventions that unveil new mechanistic insights.