Natalie Vivien Gunter, Yee Swen Ong, Zee Wei Lai, Hiroyuki Morita, Sunita Chamyuang, Amorn Owatworakit, Siau Hui Mah
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引用次数: 0
Abstract
Over the past decade, species of Cordyceps, particularly C. sinensis, C. militaris, and C. cicadae, along with their bioactive components cordycepin, ergosterol and polysaccharides, have shown significant anti-cancer potential. These effects are mediated through mechanisms including apoptosis induction, cell cycle arrest, and modulation of key signalling pathways, as reviewed here. Notably, the bioactive components exhibit greater potency than crude extracts, with cordycepin being a promising chemotherapeutic lead. Future investigations into the in vivo efficacy and safety profiles of Cordyceps extracts and their bioactive components are greatly encouraged. Additionally, structural modification of cordycepin may offer opportunities to enhance its therapeutic potential.
期刊介绍：
The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures.
All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.
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