Association of omega-3, omega-6 fatty acids intakes and omega-6: omega-3 ratio with the prevalence of suicidal ideation: mediating role of C-reactive protein.
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Abstract
Background: Although dietary omega fatty acids have been recognized for positive effects on mental health, the specific association between omega fatty acids intake and suicidal ideation remains ambiguous. This study aims to explore the potential association between the prevalence of suicidal ideation and dietary omega fatty acids intake in American adults.
Methods: The data of 27,944 American adults collected from National Health and Nutrition Examination Survey (NHANES) were analyzed in this study. To assess the association between dietary omega fatty acids intake and suicidal ideation as measured by Item 9 of PHQ-9, logistic regression, restricted cubic spline regression, and stratified analyses, mediation analyses were employed.
Results: Logistic regression analyses indicate that the intakes of omega-3 and omega-6 fatty acids were inversely associated with the prevalence of suicidal ideation, and dietary omega-6/omega-3 ratio was positively associated with the prevalence of suicidal ideation. Subgroup analyses further revealed a stronger association between suicidal ideation and omega fatty acids intake in individuals with a history of stroke. Furthermore, a saturation effect and non-linear association were identified between omega-3 and omega-6 fatty acids intake and the prevalence of suicidal ideation, characterized by an L-shaped curve with an inflection point at 1.36 g/d, 13.69 g/d, respectively. Notably, C-reactive protein (CRP) partially mediated the association between omega-6, omega-3 fatty acids intake and suicidal ideation by a proportion of 3.8% and 4.0%.
Conclusion: The findings of this study suggest that higher omega-3 and omega-6 fatty acids intake and lower omega-6/omega-3 ratio is associated with a declined prevalence of suicidal ideation.
期刊介绍：
Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds.
Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.
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