Neuroprotective furanones from a soil-derived fungus Penicillium paxilli ga254.

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-05-15 DOI:10.1080/10286020.2025.2501025

Guang Li, Ya-Jing Wang, Si-Qian Zhou, Xiao-Qian Wu, Jing Li, Wen-Xuan Wang, Hong-Ping Long

引用次数: 0

Abstract

Three furanone derivatives (1-3), including one new compound, penicifuranone A (1), and one new natural product (2), along with one known dihydropyranone (4) were isolated from the solid rice medium fermentation of Penicillium paxilli ga254. The structures of these compounds were elucidated using comprehensive NMR spectroscopic analysis. This study represents the first report of these furanone derivatives from this fungus. Additionally, the neuroprotective effects of these compounds against oxygen-glucose deprivation/reperfusion injury in pheochromocytoma-12 cells were investigated.

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从土壤真菌青霉paxilli ga254中提取神经保护呋喃酮。

从paxilli青霉ga254的固体培养基发酵中分离到三个呋喃酮衍生物（1-3），包括一个新化合物penicifuranone A(1)和一个新的天然产物(2)，以及一个已知的二氢吡喃酮(4)。这些化合物的结构通过核磁共振光谱分析得到了证实。本研究首次报道了这种真菌的呋喃酮衍生物。此外，我们还研究了这些化合物对嗜铬细胞-12细胞氧-葡萄糖剥夺/再灌注损伤的神经保护作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.