Isolation and characterization of a new diketopiperazine from Cephalotrichum sp. RD-ZLM03 isolated in Jinlun cave.

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-05-15 DOI:10.1080/10286020.2025.2497284

Yi Hao, Pei-Hai Li, Rong-Xiang Wu, Cai-Xia Wei, Ting Shu, Fan-Dong Kong, Pei Wang, Li-Man Zhou

引用次数: 0

Abstract

A new diketopiperazine, spirotryprostatin C (1), as well as nine known compounds (2-10), were isolated from the fermentation broth of the karst cave derived fungus Cephalotrichum sp. RD-ZLM03. Their structures were determined based on spectroscopic and X-ray diffraction analysis. Compounds 2, 4, 5, 6, 8, 9, and 10 showed significant proangiogenic activities at the concentration of 25 μM in the zebrafish model.

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金仑洞头菌RD-ZLM03中一种新型二酮哌嗪的分离与表征。

从喀斯特洞源真菌头真菌RD-ZLM03发酵液中分离得到一个新的双酮哌嗪类化合物spirotryprostatin C(1)和9个已知化合物（2 ~ 10）。通过光谱和x射线衍射分析确定了它们的结构。化合物2、4、5、6、8、9和10在25 μM浓度下对斑马鱼模型具有显著的促血管生成活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.