Miriam Merenciano, Anaïs Larue, Chloé Garambois, William Vilas Boas Nunes, Cristina Vieira
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Abstract
Ageing is a gradual biological process marked by a decline in physiological function, increasing susceptibility to disease, and mortality. Transposable elements (TEs) are repetitive DNA sequences capable of moving within the genome and thus potentially inducing mutations and disrupting normal cellular functions. Their mobile nature contributes to genomic variation, as transposition events can alter gene expression, chromosome structure, and the epigenetic landscape. To mitigate TE-induced damage, cells rely on epigenetic mechanisms, such as DNA methylation, histone modifications, and small RNAs, to repress TE activity. However, these silencing mechanisms become less effective with age, leading to increased TE activation. This review explores the dual role of TEs as both a cause and consequence of ageing, suggesting a complex relationship between TEs and the ageing process.
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About the journal
Genome Biology and Evolution (GBE) publishes leading original research at the interface between evolutionary biology and genomics. Papers considered for publication report novel evolutionary findings that concern natural genome diversity, population genomics, the structure, function, organisation and expression of genomes, comparative genomics, proteomics, and environmental genomic interactions. Major evolutionary insights from the fields of computational biology, structural biology, developmental biology, and cell biology are also considered, as are theoretical advances in the field of genome evolution. GBE’s scope embraces genome-wide evolutionary investigations at all taxonomic levels and for all forms of life — within populations or across domains. Its aims are to further the understanding of genomes in their evolutionary context and further the understanding of evolution from a genome-wide perspective.
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