ESBL/pAmpC-producing Enterobacterales in common leopard geckos (Eublepharis macularius) and central bearded dragons (Pogona vitticeps) from Portugal.

IF 2.6 2区农林科学 Q1 VETERINARY SCIENCES

Frontiers in Veterinary Science Pub Date : 2025-04-30 eCollection Date: 2025-01-01 DOI:10.3389/fvets.2025.1579193

Andreia Valença, Gonçalo Fernandes, Joaquim Smolders, Rui Patrício, Adriana Belas

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引用次数: 0

Abstract

Common leopard geckos (Eublepharis macularius) and central bearded dragon (Pogona vitticeps) are widely kept as pets but can harbor pathogenic bacteria, including antimicrobial-resistant (AMR) bacteria. This study aimed to research the frequency of β-lactamase-producing Enterobacterales in these two reptile species. A total of 132 samples were collected from the oral and cloacal cavities of healthy common leopard geckos and central bearded dragons in the Lisbon area, Portugal. Antimicrobial resistance was assessed for third-generation cephalosporin (3GC)-resistant Enterobacterales. The results revealed that 3GC-resistant Enterobacterales were observed in 17.9% (n = 14/78) of the reptiles. The most commonly identified species were: Citrobacter freundii and Klebsiella aerogenes. Furthermore, some isolates produced extended-spectrum β-lactamases (ESBLs) and AmpC β-lactamases (AmpC) encoding genes such as bla _CMY-2, bla _CTX-M-15, and bla _TEM-1. These findings emphasize the potential role of these reptiles in the spread of AMR bacteria, particularly in urban settings where human- animal interactions are frequent. Given the zoonotic risks, this study emphasizes the importance of continued surveillance and responsible antimicrobial use in both veterinary and human medicine to mitigate the spread of AMR bacteria.

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产ESBL/ pampc肠杆菌在葡萄牙常见豹纹壁虎（Eublepharis macularius）和中央胡须龙（Pogona vitticeps）。

常见的豹纹壁虎（Eublepharis macularius）和中央胡须龙（Pogona vitticeps）被广泛作为宠物饲养，但它们可能携带致病菌，包括抗菌素耐药性（AMR）细菌。本研究旨在研究这两种爬行动物中产β-内酰胺酶肠杆菌的频率。在葡萄牙里斯本地区，从健康的普通豹纹壁虎和中央胡须龙的口腔和阴道腔中收集了132个样本。对第三代头孢菌素（3GC）耐药肠杆菌进行耐药性评估。结果显示，17.9% （n = 14/78）的爬行动物检出3gc耐药肠杆菌。最常见的菌种是：弗氏柠檬酸杆菌和产气克雷伯菌。此外，部分分离株产生广谱β-内酰胺酶（ESBLs）和AmpC β-内酰胺酶（AmpC），编码bla CMY-2、bla CTX-M-15和bla TEM-1等基因。这些发现强调了这些爬行动物在AMR细菌传播中的潜在作用，特别是在人与动物频繁互动的城市环境中。鉴于人畜共患风险，本研究强调了在兽药和人用药中持续监测和负责任地使用抗微生物药物以减轻抗菌素耐药性细菌传播的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Veterinary Science Veterinary-General Veterinary

CiteScore

4.80

自引率

9.40%

发文量

1870

审稿时长

14 weeks

期刊介绍： Frontiers in Veterinary Science is a global, peer-reviewed, Open Access journal that bridges animal and human health, brings a comparative approach to medical and surgical challenges, and advances innovative biotechnology and therapy. Veterinary research today is interdisciplinary, collaborative, and socially relevant, transforming how we understand and investigate animal health and disease. Fundamental research in emerging infectious diseases, predictive genomics, stem cell therapy, and translational modelling is grounded within the integrative social context of public and environmental health, wildlife conservation, novel biomarkers, societal well-being, and cutting-edge clinical practice and specialization. Frontiers in Veterinary Science brings a 21st-century approach—networked, collaborative, and Open Access—to communicate this progress and innovation to both the specialist and to the wider audience of readers in the field. Frontiers in Veterinary Science publishes articles on outstanding discoveries across a wide spectrum of translational, foundational, and clinical research. The journal''s mission is to bring all relevant veterinary sciences together on a single platform with the goal of improving animal and human health.