Effects of bile acids on production performance, serum biochemistry, lipid metabolism, and intestinal morphology in broilers.

IF 2.6 2区农林科学 Q1 VETERINARY SCIENCES

Frontiers in Veterinary Science Pub Date : 2025-04-30 eCollection Date: 2025-01-01 DOI:10.3389/fvets.2025.1584544

Wenjing Liu, Xinan Li, Yunlong Zhang, Tao Li, Yuqiang Wei, Xuejun Yuan, Yang Li, Weiren Yang, Ning Jiao

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Abstract

The objective of the present study was to evaluate the effects of exogenous bile acids (BAs) on production performance, serum biochemistry, lipid metabolism, and intestinal morphology in broilers. A total of 20,000 one-day-old Arbor Acres broilers were randomly assigned to two treatment groups, with eight replicates of 1,250 chicks each, for a duration of 42 days. The control group broilers were provided with normal drinking water, while the treatment group broilers were provided with drinking water supplemented with 100 mL of BAs per ton. The results showed that BAs supplementation significantly decreased abdominal fat yield (p < 0.05), while having no significant effect on other slaughter characteristics (p > 0.05). In addition, BAs supplementation significantly decreased serum acrylic aminotransferase concentrations (p < 0.05). Moreover, BAs supplementation also significantly decreased the mRNA expression of lipogenesis-related genes (p < 0.05) and increased the mRNA expression of lipolysis-related genes in the liver (p < 0.05). Furthermore, BAs supplementation significantly improved jejunal morphology by increasing jejunum villus height (VH) (p < 0.05). In summary, BAs supplementation improved production performance, serum enzyme activity, lipid metabolism, and intestinal morphology in broilers, providing a theoretical basis for the application of BAs in broiler production.

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胆汁酸对肉鸡生产性能、血清生化、脂质代谢和肠道形态的影响。

本研究旨在探讨外源性胆汁酸对肉鸡生产性能、血清生化、脂质代谢和肠道形态的影响。选取2万只1日龄爱拔益加肉仔鸡，随机分为2个处理组，每组8个重复，每组1250只鸡，试验期42 d。对照组饲喂正常饮水，试验组饲喂每吨添加100 mL BAs的饮水。结果表明，添加BAs显著降低了腹部脂肪产量（p p > 0.05）。此外，添加BAs显著降低了血清丙烯转氨酶浓度(p p p p

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来源期刊

Frontiers in Veterinary Science Veterinary-General Veterinary

CiteScore

4.80

自引率

9.40%

发文量

1870

审稿时长

14 weeks

期刊介绍： Frontiers in Veterinary Science is a global, peer-reviewed, Open Access journal that bridges animal and human health, brings a comparative approach to medical and surgical challenges, and advances innovative biotechnology and therapy. Veterinary research today is interdisciplinary, collaborative, and socially relevant, transforming how we understand and investigate animal health and disease. Fundamental research in emerging infectious diseases, predictive genomics, stem cell therapy, and translational modelling is grounded within the integrative social context of public and environmental health, wildlife conservation, novel biomarkers, societal well-being, and cutting-edge clinical practice and specialization. Frontiers in Veterinary Science brings a 21st-century approach—networked, collaborative, and Open Access—to communicate this progress and innovation to both the specialist and to the wider audience of readers in the field. Frontiers in Veterinary Science publishes articles on outstanding discoveries across a wide spectrum of translational, foundational, and clinical research. The journal''s mission is to bring all relevant veterinary sciences together on a single platform with the goal of improving animal and human health.