Human papillomavirus in canine serum: evidence from a Chinese study.

IF 2.6 2区农林科学 Q1 VETERINARY SCIENCES

Frontiers in Veterinary Science Pub Date : 2025-04-30 eCollection Date: 2025-01-01 DOI:10.3389/fvets.2025.1511289

Yumeng Liu, Lulu Xie, Yimin Zhou, Lin Zhou, Jingshan Bi, Min Zheng, Tian Lan, Wenchao Sun

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引用次数: 0

Abstract

Introduction: Human papillomaviruses (HPVs) are well-known for causing both benign and malignant epithelial growths in humans, but their occurrence in non-human species is rarely reported. Expanding the understanding of HPV's host range is essential for assessing its ecological and public health implications.

Methods: We investigated serum samples from dogs collected in Guangxi, China, between 2014 and 2020. PCR screening was performed to detect HPV DNA, followed by sequencing and phylogenetic analysis of the positive amplicons.

Results: HPV DNA was unexpectedly detected in 2 out of 1,226 canine serum samples, yielding a detection rate of 0.16%. Phylogenetic analysis revealed that the sequences clustered with alpha2-HPV78 (GX-70-related) and alpha2-HPV94 (GX-47-related), respectively. Interestingly, both sequences displayed multiple amino acid variations in viral proteins. However, virus isolation was not achieved.

Discussion: The detection of HPV nucleic acids in canine serum suggests a potential presence of HPV in canine hosts. These findings provide new insights into the possible host range of HPV, underscoring the need for further research to assess the virus's infectivity, transmission dynamics, and implications for both animal and human health.

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犬血清中的人乳头瘤病毒：来自中国研究的证据。

导读：众所周知，人乳头瘤病毒（hpv）可引起人类良性和恶性上皮生长，但其在非人类物种中的发生很少报道。扩大对HPV宿主范围的了解对于评估其生态和公共卫生影响至关重要。方法：对2014 - 2020年在广西采集的犬血清样本进行调查。PCR检测HPV DNA，对阳性扩增子进行测序和系统发育分析。结果：1226份犬血清样本中有2份意外检出HPV DNA，检出率为0.16%。系统发育分析显示，该序列分别与gx -70相关的alpha2-HPV78和gx -47相关的alpha2-HPV94聚类。有趣的是，这两个序列都显示出病毒蛋白中的多个氨基酸变异。但是，没有实现病毒分离。讨论：犬血清中HPV核酸的检测提示犬宿主中可能存在HPV。这些发现为HPV可能的宿主范围提供了新的见解，强调需要进一步研究以评估病毒的传染性、传播动力学以及对动物和人类健康的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Veterinary Science Veterinary-General Veterinary

CiteScore

4.80

自引率

9.40%

发文量

1870

审稿时长

14 weeks

期刊介绍： Frontiers in Veterinary Science is a global, peer-reviewed, Open Access journal that bridges animal and human health, brings a comparative approach to medical and surgical challenges, and advances innovative biotechnology and therapy. Veterinary research today is interdisciplinary, collaborative, and socially relevant, transforming how we understand and investigate animal health and disease. Fundamental research in emerging infectious diseases, predictive genomics, stem cell therapy, and translational modelling is grounded within the integrative social context of public and environmental health, wildlife conservation, novel biomarkers, societal well-being, and cutting-edge clinical practice and specialization. Frontiers in Veterinary Science brings a 21st-century approach—networked, collaborative, and Open Access—to communicate this progress and innovation to both the specialist and to the wider audience of readers in the field. Frontiers in Veterinary Science publishes articles on outstanding discoveries across a wide spectrum of translational, foundational, and clinical research. The journal''s mission is to bring all relevant veterinary sciences together on a single platform with the goal of improving animal and human health.